O57932

PR
Gene name
amyA (PH0193)
Protein name
Alpha-amylase
Names
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0193
EC number
3.2.1.1: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

417-493 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O57932

Entry ID Method Resolution Chain Position Source
AF-O57932-F1 Predicted AlphaFoldDB

No variants for O57932

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57932

No associated diseases with O57932

3 regional properties for O57932

Type Name Position InterPro Accession
domain Glycoside hydrolase family 57, N-terminal domain 21 - 268 IPR004300
domain Alpha-amylase/4-alpha-glucanotransferase, central domain 311 - 382 IPR015178
domain Alpha-amylase/4-alpha-glucanotransferase, C-terminal 392 - 626 IPR015179

Functions

Description
EC Number 3.2.1.1 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
alpha-amylase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

1 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPRINFIFGV HNHQPLGNFE WIIKRAYEKA YRPFLETLEE YPNMKVAVHI SGVLVEWLER
70 80 90 100 110 120
NRPEYIDLLK SLIKKGQVEL VVAGFYEPIL VAIPEEDRVE QIKLSKGWAR KMGYEARGLW
130 140 150 160 170 180
LTERVWEPEL VKTLREAGIE YVILDDYHFM SAGLSKEELF WPYYTENGGE AIVVFPIDEK
190 200 210 220 230 240
LRYLIPFRPV NETLEYLHSL ADEDESKVAV FHDDGEKFGA WPGTHELVYE RGWLKEFFDR
250 260 270 280 290 300
ISSDDKINLM LYSEYLSKFR PKGLVYLPIA SYFEMSEWSL PARQAKLFFE FIKKLKELNL
310 320 330 340 350 360
FEKYRIFVRG GIWKNFLYKY PEGNYMHKRM LMLSKLLRNN PTARIFVLRA QCNDAYWHGV
370 380 390 400 410 420
FGGIYLPHIR RAVWRNLIKA HSYLEPENRV FDLDFDGGEE IMLENENFIL VVKPHYGGAI
430 440 450 460 470 480
FEMSSKKKYV NYLDVVARRW EHYHSLKDIP EGMKRELSYD KWPRGMLQDH FLLPTEVLDN
490 500 510 520 530 540
YMLSKYRELG DFLMSSYHYQ IEDKLRLWRS GKVKGISVEV EKVLRLNKDG FTTEYRIVSK
550 560 570 580 590 600
EELGLMFGVE INLAVQGTVE YPAEFMSKEI EVKDIFGKVK IESEKEAKIW KFPIKTLSQS
610 620 630
ESGWDFVQQG VSYTFLYPIE KMLNIKLKFK ESM