O57861

PR
Gene name
polC (PH0121)
Protein name
DNA polymerase II large subunit
Names
Pol II, Exodeoxyribonuclease large subunit
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0121
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1363-1431 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O57861

Entry ID Method Resolution Chain Position Source
3O59 X-ray 220 A X 1-297 PDB
5BKH X-ray 243 A A 944-1123 PDB
7OEC X-ray 148 A A 951-1117 PDB
AF-O57861-F1 Predicted AlphaFoldDB

No variants for O57861

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57861

No associated diseases with O57861

6 regional properties for O57861

Type Name Position InterPro Accession
domain Hint domain C-terminal 1073 - 1123 IPR003586
domain Hint domain N-terminal 950 - 1072 IPR003587
domain HNH nuclease 696 - 734 IPR003615
ptm Intein N-terminal splicing region 952 - 1048 IPR006141
domain DNA polymerase II large subunit DP2, N-terminal 9 - 951 IPR016033
domain Intein C-terminal splicing region 1095 - 1118 IPR030934

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exodeoxyribonuclease I activity Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides.
identical protein binding Binding to an identical protein or proteins.

3 GO annotations of biological process

Name Definition
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELPKEMEEY FSMLQREIDK AYEIAKKARA QGKDPSLDVE IPQASDMAGR VESLVGPPGV
70 80 90 100 110 120
AERIRELVKE YGKEIAALKI VDEIIDGKFG DLGSKEKYAE QAVRTALAIL TEGVVSAPIE
130 140 150 160 170 180
GIASVKIKRN TWSDNSEYLA LYYAGPIRSS GGTAQALSVL VGDYVRRKLG LDRFKPSEKH
190 200 210 220 230 240
IERMVEEVDL YHRTVSRLQY HPSPEEVRLA MRNIPIEITG EATDEVEVSH RDIPGVETNQ
250 260 270 280 290 300
LRGGAILVLA EGVLQKAKKL VKYIDKMGIE GWEWLKEFVE AKEKGEEIEE EGSAESTVEE
310 320 330 340 350 360
TKVEVDMGFY YSLYQKFKSE IAPNDKYAKE IIGGRPLFSD PSRNGGFRLR YGRSRVSGFA
370 380 390 400 410 420
TWGINPATMI LVDEFLAIGT QLKTERPGKG AVVTPVTTIE GPIVKLKDGS VVKVDDYKLA
430 440 450 460 470 480
LKIRDEVEEI LYLGDAVIAF GDFVENNQTL LPANYCEEWW ILEFTKALNE IYEVELKPFE
490 500 510 520 530 540
VNSSEDLEEA ADYLEVDIEF LKELLKDPLR TKPPVELAIH FSEILGIPLH PYYTLYWNSV
550 560 570 580 590 600
KPEQVEKLWR VLKEHAHIDW DNFRGIKFAR RIVIPLEKLR DSKRALELLG LPHKVEGKNV
610 620 630 640 650 660
IVDYPWAAAL LTPLGNLEWE FRAKPLHTTI DIINENNEIK LRDRGISWIG ARMGRPEKAK
670 680 690 700 710 720
ERKMKPPVQV LFPIGLAGGS SRDIKKAAEE GKVAEVEIAL FKCPKCGHVG PEHICPNCGT
730 740 750 760 770 780
RKELIWVCPR CNAEYPESQA SGYNYTCPKC NVKLKPYAKR KIKPSELLKR AMDNVKVYGI
790 800 810 820 830 840
DKLKGVMGMT SGWKMPEPLE KGLLRAKNDV YVFKDGTIRF DATDAPITHF RPREIGVSVE
850 860 870 880 890 900
KLRELGYTHD FEGNPLVSED QIVELKPQDI ILSKEAGKYL LKVAKFVDDL LEKFYGLPRF
910 920 930 940 950 960
YNAEKMEDLI GHLVIGLAPH TSAGIVGRII GFVDALVGYA HPYFHAAKRR NCFPGDTRIL
970 980 990 1000 1010 1020
VQINGTPQRV TLKELYELFD EEHYESMVYV RKKPKVDIKV YSFNPEEGKV VLTDIEEVIK
1030 1040 1050 1060 1070 1080
APATDHLIRF ELELGSSFET TVDHPVLVYE NGKFVEKRAF EVREGNIIII IDESTLEPLK
1090 1100 1110 1120 1130 1140
VAVKKIEFIE PPEDFVFSLN AKKYHTVIIN ENIVTHQCDG DEDAVMLLLD ALLNFSRYYL
1150 1160 1170 1180 1190 1200
PEKRGGKMDA PLVITTRLDP REVDSEVHNM DIVRYYPLEF YEATYELKSP KELVGVIERV
1210 1220 1230 1240 1250 1260
EDRLGKPEMY YGLKFTHDTD DIALGPKMSL YKQLGDMEEK VKRQLDVARR IRAVDEHKVA
1270 1280 1290 1300 1310 1320
ETILNSHLIP DLRGNLRSFT RQEFRCVKCN TKFRRPPLDG KCPICGGKIV LTVSKGAIEK
1330 1340 1350 1360 1370 1380
YLGTAKMLVT EYKVKNYTRQ RICLTERDID SLFETVFPET QLTLLVNPND ICQRIIMERT
1390 1400 1410 1420 1430
GGSKKSGLLE NFANGYNKGK KEEMPKKQRK KEQEKSKKRK VISLDDFFSR K