O57765

PR
Gene name
nadB (PH0015)
Protein name
L-aspartate oxidase
Names
LASPO, Quinolinate synthase B
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0015
EC number
1.4.3.16: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O57765

Entry ID Method Resolution Chain Position Source
AF-O57765-F1 Predicted AlphaFoldDB

No variants for O57765

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57765

No associated diseases with O57765

2 regional properties for O57765

Type Name Position InterPro Accession
domain FAD-dependent oxidoreductase 2, FAD binding domain 8 - 349 IPR003953
domain Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal 423 - 449 IPR015939

Functions

Description
EC Number 1.4.3.16 With oxygen as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
L-aspartate oxidase activity Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide.
L-aspartate:fumarate oxidoreductase activity Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMEMRVGIVG GGLAGLTAAI ALAEKGFDVS IIGPRSTDSN SYLAQAGIAL PLLEGDSIRI
70 80 90 100 110 120
HVLDTIKAGK YINDEEIVWN VISKSSEAHD FLTSHGVTFT GNELEGGHSY PRIFTIKSET
130 140 150 160 170 180
GKHIIPILEK HARELDVNFI RGFVEEIGIN NGKLAGVFLQ GELLKFDAVV IAAGGFSGLY
190 200 210 220 230 240
RFTAGVKNNI GLLIGDVALK GVPLRDMEFV QFHPTGFIGK RTYLITEAVR GAGAKLVTGD
250 260 270 280 290 300
GERFVNELET RDIVARAIYM KMLEGKGVFL DARGIENFKD RFPYIYSVLR GEGINPEKDL
310 320 330 340 350 360
IPITPVAHYT IGGISVDAFY RTRIKGLYAI GESACNGFHG ANRLASNSLL ECVVSGLEVA
370 380 390 400 410 420
RTISREKPKR EVNDAPYSFN ELGDVDSIRE VLWNHAGIVR DEWSLREGLR KLKEIEVDER
430 440 450 460
LKLVAKAVII SALKREESRG AHYRKDYPFM RKEFEHSSFF YPNV