O57734

PR
Gene name
alaXL (PH1969)
Protein name
Alanyl-tRNA editing protein AlaX-L
Names
AlaX-L, Alanyl-tRNA deacylase AlaX-L
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH1969
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

337-404 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O57734

Entry ID Method Resolution Chain Position Source
AF-O57734-F1 Predicted AlphaFoldDB

No variants for O57734

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57734

No associated diseases with O57734

4 regional properties for O57734

Type Name Position InterPro Accession
domain DHHA1 domain 276 - 401 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 189 - 232 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 17 - 95 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 245 IPR018165

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVERVYYKDP YLREIDAKIV DVRKEKDRVE VVLDRTIFYP EGGGQPGDRG VIKGNDFEIM
70 80 90 100 110 120
VEDTIEKNGE IFHIGKLRGE IPKEGEKVKL YLDWEWRYGN MQMHTGQHIL SAVLKKLYDL
130 140 150 160 170 180
DTTGFNIFRD YAKIEVNGEV NWDMIERAEL EVNKIIINDL PVVIEEYDKL PEEIALKLRK
190 200 210 220 230 240
NVTKVKEKIR IVKIGDVDVT PCGGTHVKST REVGIIKVLR FYKKSKNLWR IEFTCGYRAI
250 260 270 280 290 300
SKMNEILRDY WGSLDLMPNK NPPLIERINE VLRTVNSLEN RIEELRREIW EWKGKALLKE
310 320 330 340 350 360
GVKVGNYTVI THVENWNMKD AQAFAIDFVK KNSNTILLLA NEKYVLFAKN EGVPVSMREL
370 380 390 400
LKEVIDELGG KGGGTDNLAR GRVEAKPEEI FDVALEKLRS HLQV