O57382

PR
Gene name
tll2 (xld)
Protein name
Tolloid-like protein 2
Names
Metalloprotease xolloid, Xenopus tolloid
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399469
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O57382

Entry ID Method Resolution Chain Position Source
AF-O57382-F1 Predicted AlphaFoldDB

No variants for O57382

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57382

No associated diseases with O57382

16 regional properties for O57382

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 595 - 606 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 750 - 761 IPR000152-2
domain EGF-like domain 579 - 620 IPR000742-1
domain EGF-like domain 738 - 775 IPR000742-2
domain CUB domain 354 - 466 IPR000859-1
domain CUB domain 467 - 579 IPR000859-2
domain CUB domain 623 - 735 IPR000859-3
domain CUB domain 779 - 891 IPR000859-4
domain CUB domain 892 - 1008 IPR000859-5
domain Peptidase M12A 153 - 352 IPR001506
domain EGF-like calcium-binding domain 579 - 620 IPR001881-1
domain EGF-like calcium-binding domain 735 - 775 IPR001881-2
domain Peptidase, metallopeptidase 158 - 300 IPR006026
conserved_site EGF-like calcium-binding, conserved site 579 - 604 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 735 - 759 IPR018097-2
domain Tolloid/BMP1 peptidase domain 153 - 352 IPR034036

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSCGSPQVMM TLWTLTCVGL ILLGAIRLSL GLDYDLESFD YLMEDNPEEF DYKDPCKAAA
70 80 90 100 110 120
YWGDIALDED DLKWIFKNKS NDLRNTRHNQ THPTTDNFSE KLGTGSQNET SSNLNSKKVK
130 140 150 160 170 180
KGSRLKLLIA EKAATETNST FQVQTSNDRV RRAATSRTER IWPGGIIPYA IAGNFTGTQR
190 200 210 220 230 240
AIFKQAMRHW KKHTCVTFVE RTDEESFIVF TYRPCGCCSY VGRRGGGPQA ISIGKNCDKF
250 260 270 280 290 300
GIVVHELGHV VGFWHEHTRP DRDEHVSIIR ENIQPGQEYN FLKMEPGEVS SLGETYDFDS
310 320 330 340 350 360
IMHYARNTFS RGVFLDTILP RRIDTSVRPT IGQRIRLSQG DIAQAKKLYK CPACGETLQD
370 380 390 400 410 420
SSGNFSAPGY PSGYPSYTHC IWRISVTPGE KIILNFTTMD LFKSRLCWYD YIEIRDGYWR
430 440 450 460 470 480
KAALLGRLCG DKLPDPIISS DSKLWIEFRS SSNILGKGFF AAYEAICGGD IKKDSGQIQS
490 500 510 520 530 540
PNYPDDYRPA KECIWKITVS EGFLVGLSFQ AFEIERHDNC AYDYLEVRDG FSEDHALIGR
550 560 570 580 590 600
FCGYEKPEDI KSTSNKLWIK FASDGSINKA GFSANFFKEM DECSRPDNGG CSQRCVNTLG
610 620 630 640 650 660
SYKCVCEPGF ELTADKKSCE AACGGFITQL NGTITSPGWP KEYPTNKNCV WQVVAPAQYR
670 680 690 700 710 720
ISLQFEVFEL EGNDVCKYDY LEIRSGLSSE SKLHGKFCGP EKPEVITSQG NTVRIEFKSD
730 740 750 760 770 780
NTVSKKGFKA NFFSDKDECS KDNGGCQHDC VNTFGSYICQ CKNGFILHEN GHDCKEAGCE
790 800 810 820 830 840
QKLLNAEGTI SSPNWPEKYP SRKECTWDIS VTAGHRVKLV FTDFEIEQHQ ECAYDHLELY
850 860 870 880 890 900
DGPNGKAAIL GRFCGSKEPS PVVASTNNMF LRFYSDASVQ RKGFQAKYSP ECGGRLKAEI
910 920 930 940 950 960
QTNDIYSHAQ FGDNNYPVQS NCEWVIVAED GYGVELIFQT FEIEEESDCG YDYMEVYDGY
970 980 990 1000 1010
DSTAPRLGRY CGSGPPEEMY SAGDSIMIRF HTDDTINKKG FHGQYTSTKF QDALHMRRK