O55189
Gene name |
Ambn |
Protein name |
Ameloblastin |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11698 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O55189
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O55189-F1 | Predicted | AlphaFoldDB |
17 variants for O55189
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388766807 | 7 | P>T | No | EVA | |
| rs3388766832 | 26 | A>S | No | EVA | |
| rs3388757260 | 85 | L>P | No | EVA | |
| rs218127480 | 86 | P>T | No | EVA | |
| rs3388766860 | 183 | F>L | No | EVA | |
| rs223946045 | 187 | R>H | No | EVA | |
| rs3388765784 | 192 | G>E | No | EVA | |
| rs264186961 | 221 | R>T | No | EVA | |
| rs3388739704 | 262 | P>S | No | EVA | |
| rs3388769661 | 266 | D>E | No | EVA | |
| rs3388761493 | 293 | Q>R | No | EVA | |
| rs245929876 | 303 | P>H | No | EVA | |
| rs3388766794 | 369 | G>S | No | EVA | |
| rs213643980 | 371 | G>R | No | EVA | |
| rs3388775404 | 384 | Q>H | No | EVA | |
| rs3388754829 | 385 | Q>H | No | EVA | |
| rs231979417 | 388 | L>I | No | EVA |
No associated diseases with O55189
No regional properties for O55189
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O55189 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| extracellular matrix structural constituent conferring compression resistance | A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
| structural constituent of tooth enamel | The action of a molecule that contributes to the structural integrity of tooth enamel. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| biomineral tissue development | Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| odontogenesis of dentin-containing tooth | The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASKIPLFK | MKGLILFLSL | VKMSLAVPAF | PQQPGAQGMA | PPGMASLSLE | TMRQLGSLQG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNALSQYSRL | GFGKALNSLW | LHGLLPPHNS | FPWIGPREHE | TQQPSLQPHQ | PGLKPFLQPT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AATGVQVTPQ | KPGPQPPMHP | GQLPLQEGEL | IAPDEPQVAP | SENPPTPEVP | IMDFADPQFP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVFQIARSIS | RGPMAHNKAS | AFYPGMFYMS | YGANQLNAPA | RIGFMSSEEM | PGERGSPMAY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GTLFPRFGGF | RQTLRRLNQN | SPKGGDFTVE | VDSPVSVTKG | PEKGEGPEGS | PLQEANPGKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENPALLSQMA | PGAHAGLLAF | PNDHIPSMAR | GPAGQRLLGV | TPAAADPLIT | PELAEVYETY |
| 370 | 380 | 390 | 400 | ||
| GADVTTPLGD | GEATMDITMS | PDTQQPLLPG | NKVHQPQVHN | AWRFQEP |