O55036

PR
Gene name
TERF1 (TRF1)
Protein name
Telomeric repeat-binding factor 1
Names
TTAGGG repeat-binding factor 1
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

233-409 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O55036

Entry ID Method Resolution Chain Position Source
AF-O55036-F1 Predicted AlphaFoldDB

No variants for O55036

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O55036

No associated diseases with O55036

3 regional properties for O55036

Type Name Position InterPro Accession
domain SANT/Myb domain 375 - 430 IPR001005
domain Telomere repeat-binding factor, dimerisation domain 77 - 269 IPR013867
domain Myb domain 375 - 432 IPR017930

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
  • Cytoplasm, cytoskeleton, spindle
  • Colocalizes with telomeric DNA in interphase and prophase cells
  • Telomeric localization decreases in metaphase, anaphase and telophase
  • Associates with the mitotic spindle via its C-terminal domain (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

2 GO annotations of molecular function

Name Definition
double-stranded telomeric DNA binding Binding to double-stranded telomere-associated DNA.
protein homodimerization activity Binding to an identical protein to form a homodimer.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEDVSSTAP SPRGCADGRD ADPTEEQMAQ TQRNDQDQFE CQELLECQVQ VGAPDEEEEE
70 80 90 100 110 120
EEDSGLVAEA EAVAAGWMLH FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL
130 140 150 160 170 180
RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIPA
190 200 210 220 230 240
IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYYHMMEKI
250 260 270 280 290 300
KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQDKPSG NDVEMETEAN LDTRKSVSDK
310 320 330 340 350 360
QSAVTESSEG TVSLLRSHKN LFLSKLQHGT QQQDLNKKER RVGTPQSTKK KKESRRATES
370 380 390 400 410 420
RIPVSKSQPV TPEKHRARKR QAWLWEEDKN LRSGVRKYGE GNWSKILLHY KFNNRTSVML
430
KDRWRTMKKL KLISSDSE