AiPD: Autoinhibited Protein Database

Gene name	Pole2
Protein name	DNA polymerase epsilon subunit 2
Names	DNA polymerase II subunit 2, DNA polymerase epsilon subunit B
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:18974
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

15-99 (Predicted disordered autoinhibitory region) PR

15-99 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O54956-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs29135637	78	M>V	No	EVA
rs3389243667	87	N>Y	No	EVA
rs3389209538	112	T>P	No	EVA
rs236242260	115	A>T	No	EVA
rs3389238593	116	A>V	No	EVA
rs3389227676	133	R>H	No	EVA
rs3389249819	145	E>D	No	EVA
rs3389240843	145	E>G	No	EVA
rs3389237041	155	H>Y	No	EVA
rs3389252168	157	E>V	No	EVA
rs3389200903	182	I>M	No	EVA
rs3389255520	195	F>C	No	EVA
rs3389173019	201	T>N	No	EVA
rs3389237025	203	T>I	No	EVA
rs3403499844	205	Q>E	No	EVA
rs3402692676	205	Q>L	No	EVA
rs3389215946	206	L>M	No	EVA
rs3389200873	212	Q>H	No	EVA
rs3389238632	245	T>A	No	EVA
rs3389237026	333	N>Y	No	EVA
rs3389200869	376	L>I	No	EVA
rs3403006821	390	R>*	No	EVA
rs3402692678	457	Y>*	No	EVA
rs3403006875	458	V>I	No	EVA
rs3403377681	459	C>*	No	EVA
rs3403519887	470	R>N	No	EVA

Type	Name	Position	InterPro Accession
domain	DNA polymerase alpha/delta/epsilon, subunit B	287 - 488	IPR007185
domain	DNA polymerase epsilon subunit B, N-terminal	3 - 74	IPR024639

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
epsilon DNA polymerase complex	A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Name	Definition
DNA-templated DNA replication	A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
error-prone translesion synthesis	The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A7YWS7	POLE2	DNA polymerase epsilon subunit 2	Bos taurus (Bovine)	PR
P56282	POLE2	DNA polymerase epsilon subunit 2	Homo sapiens (Human)	PR