O54408

PR
Gene name
relA (BSU27600)
Protein name
GTP pyrophosphokinase
Names
(p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU27600
EC number
2.7.6.5: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

531-611 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O54408

Entry ID Method Resolution Chain Position Source
6HTQ EM 450 A x 391-731 PDB
6YXA X-ray 395 A A 1-556 PDB
8ACU X-ray 297 A A/B 1-373 PDB
AF-O54408-F1 Predicted AlphaFoldDB

No variants for O54408

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O54408

No associated diseases with O54408

7 regional properties for O54408

Type Name Position InterPro Accession
domain ACT domain 654 - 734 IPR002912
domain HD/PDEase domain 46 - 171 IPR003607
domain TGS 392 - 453 IPR004095
domain HD domain 50 - 149 IPR006674
domain RelA/SpoT 219 - 350 IPR007685
domain RelA/SpoT, TGS domain 395 - 453 IPR033655
domain RelA/SpoT, AH and RIS domains 466 - 634 IPR045600

Functions

Description
EC Number 2.7.6.5 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANEQVLTAE QVIDKARSYL SDEHIAFVEK AYLYAEDAHR EQYRKSGEPY IIHPIQVAGI
70 80 90 100 110 120
LVDLEMDPST IAGGFLHDVV EDTDVTLDDL KEAFSEEVAM LVDGVTKLGK IKYKSQEEQQ
130 140 150 160 170 180
AENHRKMFVA MAQDIRVILI KLADRLHNMR TLKHLPQEKQ RRISNETLEI FAPLAHRLGI
190 200 210 220 230 240
SKIKWELEDT ALRYLNPQQY YRIVNLMKKK RAERELYVDE VVNEVKKRVE EVNIKADFSG
250 260 270 280 290 300
RPKHIYSIYR KMVLQNKQFN EIYDLLAVRI LVNSIKDCYA VLGIIHTCWK PMPGRFKDYI
310 320 330 340 350 360
AMPKPNMYQS LHTTVIGPKG DPLEVQIRTF EMHEIAEYGV AAHWAYKEGK AANEGATFEK
370 380 390 400 410 420
KLSWFREILE FQNESTDAEE FMESLKIDLF SDMVYVFTPK GDVIELPSGS VPIDFSYRIH
430 440 450 460 470 480
SEIGNKTIGA KVNGKMVTLD HKLRTGDIVE ILTSKHSYGP SQDWVKLAQT SQAKHKIRQF
490 500 510 520 530 540
FKKQRREENV EKGRELVEKE IKNLDFELKD VLTPENIQKV ADKFNFSNEE DMYAAVGYNG
550 560 570 580 590 600
ITALQVANRL TEKERKQRDQ EEQEKIVQEV TGEPKPYPQG RKREAGVRVK GIDNLLVRLS
610 620 630 640 650 660
KCCNPVPGDD IVGFITKGRG VSVHREDCPN VKTNEAQERL IPVEWEHESQ VQKRKEYNVE
670 680 690 700 710 720
IEILGYDRRG LLNEVLQAVN ETKTNISSVS GKSDRNKVAT IHMAIFIQNI NHLHKVVERI
730
KQIRDIYSVR RVMN