O53857
Gene name |
narS |
Protein name |
Sensor histidine kinase NarS |
Names |
|
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv0845 |
EC number |
2.7.13.3: Protein-histidine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O53857
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O53857-F1 | Predicted | AlphaFoldDB |
No variants for O53857
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O53857 | |||||
No associated diseases with O53857
7 regional properties for O53857
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Twin-arginine translocation pathway, signal sequence | 1 - 31 | IPR006311 |
| domain | Molybdopterin oxidoreductase | 96 - 568 | IPR006656 |
| domain | Molybdopterin dinucleotide-binding domain | 714 - 822 | IPR006657 |
| domain | Molybdopterin oxidoreductase, 4Fe-4S domain | 39 - 95 | IPR006963 |
| conserved_site | Twin-arginine translocation pathway, signal sequence, bacterial/archaeal | 2 - 24 | IPR019546 |
| binding_site | Molybdopterin oxidoreductase, molybdopterin cofactor binding site | 44 - 61 | IPR027467 |
| domain | Nitrate reductase NapA-like, molybdopterin-binding domain | 711 - 828 | IPR041957 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.13.3 | Protein-histidine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein histidine kinase activity | Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorelay signal transduction system | A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSYGNLGRL | GGRHEYGVLV | AMTSSAELDR | VRWAHQLRSY | RIASVLRIGV | VGLMVAAMVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTSRSEWPQQ | IVLIGVYAVA | ALWALLLAYS | ASRRFFALRR | FRSMGRLEPF | AFTAVDVLIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGFQLLSTDG | IYPLLIMILL | PVLVGLDVST | RRAAVVLACT | LVGFAVAVLG | DPVMLRAIGW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PETIFRFALY | AFLCATALMV | VRIEERHTRS | VAGLSALRAE | LLAQTMTASE | VLQRRIAEAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HDGPLQDVLA | ARQELIELDA | VTPGDERVGR | ALAGLQSASE | RLRQATFELH | PAVLEQVGLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PAVKQLAAST | AQRSGIKIST | DIDYPIRSGI | DPIVFGVVRE | LLSNVVRHSG | ATTASVRLGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TDEKCVLDVA | DDGVGVTGDT | MARRLGEGHI | GLASHRARVD | AAGGVLVFLA | TPRGTHVCVE |
| LPLKR |