O53585

PR
Gene name
glfT2
Protein name
Galactofuranosyltransferase GlfT2
Names
GalTr 2, Arabinogalactan galactosyltransferase 2, Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase, Polymerizing galactofuranosyltransferase GlfT2
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3808c
EC number
2.4.1.288: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O53585

Entry ID Method Resolution Chain Position Source
4FIX X-ray 245 A A/B 1-637 PDB
4FIY X-ray 310 A A/B 1-637 PDB
AF-O53585-F1 Predicted AlphaFoldDB

No variants for O53585

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O53585

No associated diseases with O53585

2 regional properties for O53585

Type Name Position InterPro Accession
domain Galactofuranosyltransferase GlfT2, N-terminal 9 - 152 IPR040492
domain Galactofuranosyltransferase-2, C-terminal 435 - 625 IPR045699

Functions

Description
EC Number 2.4.1.288 Hexosyltransferases
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
lipopolysaccharide-1,5-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide.
lipopolysaccharide-1,6-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide.
metal ion binding Binding to a metal ion.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
UDP-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.

7 GO annotations of biological process

Name Definition
capsule polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi.
cell wall macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall.
lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
mycolate cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer.
UDP-D-galactose metabolic process The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSELAASLLS RVILPRPGEP LDVRKLYLEE STTNARRAHA PTRTSLQIGA ESEVSFATYF
70 80 90 100 110 120
NAFPASYWRR WTTCKSVVLR VQVTGAGRVD VYRTKATGAR IFVEGHDFTG TEDQPAAVET
130 140 150 160 170 180
EVVLQPFEDG GWVWFDITTD TAVTLHSGGW YATSPAPGTA NIAVGIPTFN RPADCVNALR
190 200 210 220 230 240
ELTADPLVDQ VIGAVIVPDQ GERKVRDHPD FPAAAARLGS RLSIHDQPNL GGSGGYSRVM
250 260 270 280 290 300
YEALKNTDCQ QILFMDDDIR LEPDSILRVL AMHRFAKAPM LVGGQMLNLQ EPSHLHIMGE
310 320 330 340 350 360
VVDRSIFMWT AAPHAEYDHD FAEYPLNDNN SRSKLLHRRI DVDYNGWWTC MIPRQVAEEL
370 380 390 400 410 420
GQPLPLFIKW DDADYGLRAA EHGYPTVTLP GAAIWHMAWS DKDDAIDWQA YFHLRNRLVV
430 440 450 460 470 480
AAMHWDGPKA QVIGLVRSHL KATLKHLACL EYSTVAIQNK AIDDFLAGPE HIFSILESAL
490 500 510 520 530 540
PQVHRIRKSY PDAVVLPAAS ELPPPLHKNK AMKPPVNPLV IGYRLARGIM HNLTAANPQH
550 560 570 580 590 600
HRRPEFNVPT QDARWFLLCT VDGATVTTAD GCGVVYRQRD RAKMFALLWQ SLRRQRQLLK
610 620 630
RFEEMRRIYR DALPTLSSKQ KWETALLPAA NQEPEHG