O53580

PR
Gene name
fadD32 (Rv3801c)
Protein name
Long-chain-fatty-acid--AMP ligase FadD32
Names
FAAL, Acyl-AMP synthetase, FAAL32
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3801c
EC number
6.2.1.20: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

132-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O53580

Entry ID Method Resolution Chain Position Source
5HM3 X-ray 225 A A 2-637 PDB
AF-O53580-F1 Predicted AlphaFoldDB

No variants for O53580

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O53580

No associated diseases with O53580

1 regional properties for O53580

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 34 - 497 IPR000873

Functions

Description
EC Number 6.2.1.20 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
long-chain fatty acid [acyl-carrier-protein] ligase activity Catalysis of the reaction: ATP + an acid

4 GO annotations of biological process

Name Definition
Actinobacterium-type cell wall biogenesis +A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface.
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
mycolate cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFVTGESGMA YHNPFIVNGK IRFPANTNLV RHVEKWAKVR GDKLAYRFLD FSTERDGVAR
70 80 90 100 110 120
DILWSDFSAR NRAVGARLQQ VTQPGDRVAI LCPQNLDYLI SFFGALYSGR IAVPLFDPAE
130 140 150 160 170 180
PGHVGRLHAV LDDCAPSTIL TTTDSAEGVR KFIRARSAKE RPRVIAVDAV PTEVAATWQQ
190 200 210 220 230 240
PEANEETVAY LQYTSGSTRI PSGVQITHLN LPTNVVQVLN ALEGQEGDRG VSWLPFFHDM
250 260 270 280 290 300
GLITVLLASV LGHSFTFMTP AAFVRRPGRW IRELARKPGE TGGTFSAAPN FAFEHAAVRG
310 320 330 340 350 360
VPRDDEPPLD LSNVKGILNG SEPVSPASMR KFFEAFAPYG LKQTAVKPSY GLAEATLFVS
370 380 390 400 410 420
TTPMDEVPTV IHVDRDELNN QRFVEVAADA PNAVAQVSAG KVGVSEWAVI VDADTASELP
430 440 450 460 470 480
DGQIGEIWLH GNNLGTGYWG KEEESAQTFK NILKSRISES RAEGAPDDAL WVRTGDYGTY
490 500 510 520 530 540
FKDHLYIAGR IKDLVIIDGR NHYPQDLECT AQESTKALRV GYAAAFSVPA NQLPQTVFDD
550 560 570 580 590 600
SHAGLKFDPE DTSEQLVIVG ERAAGTHKLD HQPIVDDIRA AIAVGHGVTV RDVLLVSAGT
610 620 630
IPRTSSGKIG RRACRAAYLD GSLRSGVGSP TVFATSD