O51508

PR
Gene name
ptsI (BB_0558)
Protein name
Phosphoenolpyruvate-protein phosphotransferase
Names
Phosphotransferase system, enzyme I
Species
Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
KEGG Pathway
bbu:BB_0558
EC number
2.7.3.9: Phosphotransferases with a nitrogenous group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O51508

Entry ID Method Resolution Chain Position Source
AF-O51508-F1 Predicted AlphaFoldDB

No variants for O51508

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O51508

No associated diseases with O51508

6 regional properties for O51508

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 256 - 542 IPR000121
domain Phosphotransferase system, enzyme I-like 3 - 568 IPR006318
domain PEP-utilising enzyme, mobile domain 153 - 223 IPR008279
domain Phosphotransferase system, enzyme I N-terminal 5 - 128 IPR008731
active_site PEP-utilising enzyme, active site 185 - 196 IPR018274
conserved_site PEP-utilising enzyme, conserved site 449 - 467 IPR023151

Functions

Description
EC Number 2.7.3.9 Phosphotransferases with a nitrogenous group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.

2 GO annotations of biological process

Name Definition
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLSGKRISK GIGIGEVLCI RKNFDKIISR EKIDFSQVDS EISKFNKAKS KAIEALRDLE
70 80 90 100 110 120
RKAMLQFGDD KKGIFEGQVL IVEDDELDEL VIELIVKENY SAAYSIYLAF ENLVKSVEDY
130 140 150 160 170 180
KDPYLKERAS DYKDIRNRLI SIILGQVSDF SEINKDIILV TEELTPSDTM QFDLNYVKGF
190 200 210 220 230 240
LTAVGGETSH AAILARTMGL PALVMTLSDI DALKDGDKIV IDAMSSIVIK NPSSDEINLY
250 260 270 280 290 300
EGKILRQVEL EKELFSLKDK DAETKDGTKV FLKANIGTPV DITYVNKYGV EGIGLFRTEF
310 320 330 340 350 360
LYMRSLQPPT EDEQFETYKR VIETMEKKGV VTIRTLDVGG DKEIPYLNFK KEENPFLGFR
370 380 390 400 410 420
ALRMYKEYEE LIQAQFNAIF RASHYGKIRV MVPMLTIYEE IETIEYFVNN AKINLKSRGL
430 440 450 460 470 480
PFDENLEVGC MIEVPSAALI SSKLANKLKF FSIGTNDLTQ YVLAVDRGNQ KISNLYDKYN
490 500 510 520 530 540
PAVLKLIKKV LDDGVSSGID VSVCGELGGD DAGALLLVGL GFRSLSMIPS ATLRIKYLLK
550 560 570
KYTIMELEEL ANKVLNSDSK QETLSYFDKF IGD