O50224

PR
Gene name
recG
Protein name
ATP-dependent DNA helicase RecG
Names
Species
Acidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O50224

Entry ID Method Resolution Chain Position Source
AF-O50224-F1 Predicted AlphaFoldDB

No variants for O50224

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O50224

No associated diseases with O50224

4 regional properties for O50224

Type Name Position InterPro Accession
domain DEAD/DEAH box helicase domain 290 - 443 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 282 - 469 IPR014001
domain ATP-dependent DNA helicase RecG, C-terminal domain 564 - 650 IPR025831
domain RecG, wedge domain 40 - 196 IPR033454

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTSTNFSQS GHVARPCRAR NSMAGAKAGL YLQSSVSALR GVGPALVPRL QHMDLWRVQD
70 80 90 100 110 120
VLFHLPSRYQ DRRHIASMAT LQAGQECAIL GEIVRVDHQR GGREQWLVTV SDGSGRLQIR
130 140 150 160 170 180
LFHMTVALRA QWQVGRRLWC FGELRGGFHG LEMIHPEWQM ADVPQFQAPR HLTPFYPSSE
190 200 210 220 230 240
GITQAQWRRW MAQALTLLDQ LPDYLENRLP PQWPGLREGL RLLHESADEI PSPQHPAWQR
250 260 270 280 290 300
LALEELLANH LAVRRMRQSG MMQNAPCLRS KGQLWHRFLA HLPFSPTMAQ ERVIAEINAD
310 320 330 340 350 360
LVRHRPMRRL LQGDVGSGKT LVAAAATLTA LEAGYQVAMM APTEILAEQL HARFQQWLEP
370 380 390 400 410 420
LGLEVGYLVG SRSPRARRET AETLAGGSLR LVIGTQSLFQ EGVVFACLGL VIIDEQHRFG
430 440 450 460 470 480
VEQRRQLLEK GAMPHLLVMT ATPIMVEDGI TVSGILLFGR TPNRFLPQAG IDAVAFPGVD
490 500 510 520 530 540
KDYAARERAA LRGPMTPLLN DAGDIVEAGL VEQAIAFVQR NTAIGGQLEE GGARRENLPA
550 560 570 580 590 600
YPREAIREAI VNALIHRDYL LSSTDIELSI YEDRLEITSP GRLPNGITPA RMLTGCRATR
610 620 630 640 650
NQLIKDVMRD YRYLEHSGMG VPRKIVKCMR EHNGTEPQLI EDGELFTVRL LR