O49836

PR
Gene name
Protein name
Phenylalanine ammonia-lyase 2
Names
PAL-2
Species
Lithospermum erythrorhizon (Purple gromwell) (Lithospermum officinale var. erythrorhizon)
KEGG Pathway
EC number
4.3.1.24: Ammonia-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

565-648 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O49836

Entry ID Method Resolution Chain Position Source
AF-O49836-F1 Predicted AlphaFoldDB

No variants for O49836

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O49836

No associated diseases with O49836

1 regional properties for O49836

Type Name Position InterPro Accession
active_site Ribonuclease T2, His active site 1 57 - 64 IPR018188

Functions

Description
EC Number 4.3.1.24 Ammonia-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.

2 GO annotations of biological process

Name Definition
cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid.
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENGNGKMEF CMKDPLNWGM AAESMKGSHL DEVKKMVAEF RKPVVQLAGK TLTIAQVAAI
70 80 90 100 110 120
AARDDGVTVE LAEAAREGVK ASSDWVMESM NKGTDSYGVT TGFGATSHRR TKQGGALQKE
130 140 150 160 170 180
LIRFLNAGIF GNGTETSHTL PHSATRAAML VRINTLLQGY SGIRFEILEA ITKFLNTNIT
190 200 210 220 230 240
PCLPLRGTIT ASGDLVPLSY IAGLLTGRPN SKAVGPTGEK LNAEEAFRLA GISSGFFELQ
250 260 270 280 290 300
PKEGLALVNG TAVGSGMASM VLYEANILGV MSEVLSAVFA EVMNGKPEFT DHLTHKLKHH
310 320 330 340 350 360
PGQIEAAAIM EHILDGSGYV KAAELLHEMD PLQKPKQDRY ALRTSPQWLG PQIEVIRSAT
370 380 390 400 410 420
KMIEREINSV NDNPLIDVSR NKALHGGNFQ GTPIGVAMDN TRLAIAAIGK LLFAQFSELV
430 440 450 460 470 480
NDYYNNGLPS NLTGSRDPSL DYGFKGAEIA MASYCSELQF LANPVTNHVQ SAEQHNQDVN
490 500 510 520 530 540
SLGLISSRKT SEAVEILKLM SSSFLVALCQ AVDLRHIEEN VRLAVKKTVS QVAKKTLNIG
550 560 570 580 590 600
VDGVLHPSRF SEKELLRVVD REYVFAYADD PCSATYPLMQ KLREVLVSHA LANSGNEKDA
610 620 630 640 650 660
STSIFHKIGV FEEELKGILP KEVENARASV ENGTPAIPNK IEECRSYPLY KFVRGELGTE
670 680 690 700
LLTGEKVRSP GEELDQVFNA LCEGKLVDPL LACLEAWNGA PLPIC