O49835
Gene name |
|
Protein name |
Phenylalanine ammonia-lyase 1 |
Names |
PAL-1 |
Species |
Lithospermum erythrorhizon (Purple gromwell) (Lithospermum officinale var. erythrorhizon) |
KEGG Pathway |
|
EC number |
4.3.1.24: Ammonia-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O49835
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O49835-F1 | Predicted | AlphaFoldDB |
No variants for O49835
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O49835 | |||||
No associated diseases with O49835
1 regional properties for O49835
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Phenylalanine/histidine ammonia-lyases, active site | 192 - 208 | IPR022313 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.3.1.24 | Ammonia-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phenylalanine ammonia-lyase activity | Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cinnamic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. |
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| METIVENGNG | KTMEFCMKDP | LNWEMASESM | KGSHLDEVKN | MVAEFRKPVV | QLAGKTLTIG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVAAIAARDD | GVTVELAEAA | REGVKASSDW | VMDSMNKGTD | SYGVTTGFGA | TSHRRTKQGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALQKELIRFL | NAGIFGNGTE | TSHTLPHSAT | RAAMLVRINT | LLQGYSGIRF | EILEAITKFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NTNITPCLPL | RGTITASGDL | VPLSYIAGLL | TGRPNSKAVG | PTGEKINAEE | AFRLAGISTG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FFELQPKEGL | ALVNGTAVGS | GMASMVLYEA | NILAVLSEVI | SAIFAEVMNG | KPEFTDHLTH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLKHHPGQIE | AAAIMEHILD | GSGYVKAAQK | LHEMDPLQKP | KQDRYALRTS | PQWLGPQIEV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRSATKMIER | EINSVNDNPL | IDVSRNKALH | GGNFQGTPIG | VAMDNTRLAI | ASIGKLLFAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSELVNDYYN | NGLPSNLTGS | RNPSLDYGFK | GAEIAMASYC | SELQFLANPV | TNHVQSAEQH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQDVNSLGLI | SSRKTSEAVE | ILKLMSSSFL | VALFQAVDLR | HIEENVRLAV | KNTVSQVAKR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLTTGVNGEL | HPSRFSEKDL | LRVVDREYVF | AYADDPCLTT | YPLMQKLRET | LVGHALDNGE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NEKDVNTSIF | HKIAIFEEEL | KAILPKEVEN | ARASVENGIP | AISNRIEECR | SYPLYKFVRE |
| 670 | 680 | 690 | 700 | ||
| ELGTELLTGE | KVRSPGEELD | KVFTAMCEGK | LVDPLLACLE | AWNGAPLPIC |