O48626

PR
Gene name
ZW10 (MIP1)
Protein name
Centromere/kinetochore protein zw10 homolog
Names
AtZW10, MAG2-interacting protein 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G32900
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

75-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O48626

Entry ID Method Resolution Chain Position Source
AF-O48626-F1 Predicted AlphaFoldDB

62 variants for O48626

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_13953816_A_G 4 I>V No 1000Genomes
tmp_2_13953821_C_G 5 D>E No 1000Genomes
ENSVATH00257674 12 N>T No 1000Genomes
ENSVATH05646755 13 V>F No 1000Genomes
ENSVATH13511838 15 D>E No 1000Genomes
tmp_2_13953909_C_A 35 R>S No 1000Genomes
ENSVATH14579685 39 N>K No 1000Genomes
tmp_2_13953936_C_T 44 H>Y No 1000Genomes
ENSVATH05646756 68 S>F No 1000Genomes
tmp_2_13954008_T_A 68 S>T No 1000Genomes
ENSVATH13511841 81 S>F No 1000Genomes
ENSVATH13511842 89 Q>K No 1000Genomes
ENSVATH05646759 100 I>L No 1000Genomes
tmp_2_13954116_G_T 104 V>L No 1000Genomes
tmp_2_13954129_C_A 108 T>K No 1000Genomes
tmp_2_13954136_G_T 110 K>N No 1000Genomes
ENSVATH13511843 113 E>K No 1000Genomes
ENSVATH01941760 142 K>N No 1000Genomes
ENSVATH01941759 142 K>T No 1000Genomes
ENSVATH14579686 149 A>P No 1000Genomes
tmp_2_13954259_G_T 151 E>D No 1000Genomes
tmp_2_13954261_G_A 152 R>K No 1000Genomes
ENSVATH01941764 174 A>V No 1000Genomes
ENSVATH13511844 198 A>V No 1000Genomes
ENSVATH00257681 208 I>L No 1000Genomes
tmp_2_13954598_G_A 232 E>K No 1000Genomes
tmp_2_13954715_G_A 235 G>E No 1000Genomes
tmp_2_13954714_G_A 235 G>R No 1000Genomes
ENSVATH05646763 241 L>F No 1000Genomes
ENSVATH00257682 249 F>V No 1000Genomes
tmp_2_13954783_A_G 258 T>A No 1000Genomes
tmp_2_13954820_G_T 270 C>F No 1000Genomes
tmp_2_13955056_T_G 304 L>R No 1000Genomes
ENSVATH01941772 325 F>L No 1000Genomes
ENSVATH00257685 362 R>Q No 1000Genomes
tmp_2_13955384_G_A 372 E>K No 1000Genomes
ENSVATH00257686 375 F>V No 1000Genomes
ENSVATH05646767 389 A>V No 1000Genomes
tmp_2_13955465_A_G 399 R>G No 1000Genomes
tmp_2_13955466_G_A 399 R>K No 1000Genomes
ENSVATH13511887 400 K>E No 1000Genomes
ENSVATH13511888 404 I>T No 1000Genomes
ENSVATH05646768 414 Q>L No 1000Genomes
tmp_2_13955629_T_G 423 I>M No 1000Genomes
tmp_2_13955631_C_A 424 A>D No 1000Genomes
ENSVATH13511889 442 V>L No 1000Genomes
tmp_2_13955841_G_C 468 V>L No 1000Genomes
tmp_2_13955845_C_G 469 A>G No 1000Genomes
ENSVATH05646770 474 N>D No 1000Genomes
tmp_2_13955895_G_A 486 V>I No 1000Genomes
tmp_2_13956057_G_A 496 D>N No 1000Genomes
tmp_2_13956097_G_A 509 C>Y No 1000Genomes
tmp_2_13956116_G_T 515 E>D No 1000Genomes
tmp_2_13956126_C_G 519 L>V No 1000Genomes
tmp_2_13956136_A_T 522 E>V No 1000Genomes
tmp_2_13956397_G_C 559 V>L No 1000Genomes
ENSVATH01941780 661 D>N No 1000Genomes
tmp_2_13957031_C_T 681 R>C No 1000Genomes
tmp_2_13957183_C_G 694 L>V No 1000Genomes
tmp_2_13957423_C_T 728 P>S No 1000Genomes
ENSVATH05646780 738 D>E No 1000Genomes
ENSVATH00257696 741 N>S No 1000Genomes

No associated diseases with O48626

No regional properties for O48626

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O48626

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm
  • Chromosome, centromere
  • Chromosome, centromere, kinetochore
  • Endoplasmic reticulum membrane; Peripheral membrane protein
  • In prometaphase, associated with the kinetochore
  • At metaphase, mostly associated with the spindle
  • In early anaphase, found in the vicinity of the centromere
  • As anaphase progresses, dispersed in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RZZ complex A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
protein exit from endoplasmic reticulum The directed movement of proteins from the endoplasmic reticulum.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEIDALFES INVRDLLAGH DLNDPTTPLS APDLRLLINR LESHSLRIKS KVQSYLVAHH
70 80 90 100 110 120
SDFSELFSLC QDTVSRTRLI SDDVSDVLQL VSDRPIDVEI RSVVDEITEK TKEVKLKRES
130 140 150 160 170 180
LDLVNAIVGI CEALQETKEA LKNGRFRFAA ERIRELKVVL RIGEEEDGEP VAYALLRKEW
190 200 210 220 230 240
SNCFDEIQEV LAKFMENAVR FELDSSRIRI KYQLSVGETA GIALSTVLEA MEVIGILDYG
250 260 270 280 290 300
LAKAADSIFK HVITPAVTHA STFAAVEDLC KSAGEVTEAT LRLEQSSDHK FEDVDGDAMY
310 320 330 340 350 360
SGILKVVKFI CSSLCFGNVT WIHSFGRLTW PRISELIISK FLSKVVPEDA SKLADFQKII
370 380 390 400 410 420
ERTSQFEAAL KELNFVSSSD AESRLSKYAE DVEVHFASRK KIEILAKARN LLLQCNFTIP
430 440 450 460 470 480
QDIAMRNAKH IVCLLFSSER CVVSEAASQL MNLVHKTLED VCVSSARVAS EFYNAARDSI
490 500 510 520 530 540
LLYEAVVPVK LEKQLDGLNE AAVLLHNDCL YLFEEILGLA FEYRASFPSS IKEYAVFADI
550 560 570 580 590 600
APRFKLMAEE VLQKQVHLVI SSLREAIDSA DGFQNTHQIK QFKSAEFSID QVVFSLKNVH
610 620 630 640 650 660
MIWEPVLRPK TYKQSMCAVL ESVFRRIARD ILLLDDMAAD ETFELQKLIY LMLKNLSSVL
670 680 690 700 710 720
DSVRSADETS RPLDDIIPSL RKTRKLAELL DMPLMSITSA WESGELFRCN FTRTEVQDFI
730 740
KAIFTDSPLR KECLWRIDEV NQ