O43102
Gene name |
cbf5 (AFUA_5G05710) |
Protein name |
H/ACA ribonucleoprotein complex subunit cbf5 |
Names |
Centromere-binding factor 5, H/ACA snoRNP protein cbf5, Small nucleolar RNP protein cbf5 |
Species |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
KEGG Pathway |
afm:AFUA_5G05710 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O43102
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O43102-F1 | Predicted | AlphaFoldDB |
No variants for O43102
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O43102 | |||||
No associated diseases with O43102
5 regional properties for O43102
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PUA domain | 274 - 348 | IPR002478 |
| domain | Pseudouridine synthase II, N-terminal | 86 - 203 | IPR002501 |
| domain | Uncharacterised domain CHP00451 | 264 - 344 | IPR004521 |
| domain | Dyskerin-like | 24 - 82 | IPR012960 |
| domain | tRNA pseudouridylate synthase B, C-terminal | 204 - 270 | IPR032819 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| box H/ACA snoRNP complex | A box H/ACA RNP complex that is located in the nucleolus. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| box H/ACA RNA 3'-end processing | Any process involved in forming the mature 3' end of a box H/ACA RNA molecule. |
| mRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. |
| rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. |
| snoRNA guided rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. |
| snRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVSVTKEEM | DYTIKPEAGA | SNISTEDWPL | LLKNYDKLMV | RTGHFTPIPA | GCSPLKRDLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SYISSGVINL | DKPSNPSSHE | VVAWMKRILR | AEKTGHSGTL | DPKVTGCLIV | CIDRATRLVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SQQGAGKEYV | CVIRLHDKIP | GGEAQFKRAL | ETLTGALFQR | PPLISAVKRQ | LRIRTIHESK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYEFDNDRHL | GVFWVSCEAG | TYIRTLCVHL | GLLLGVGAHM | QELRRVRSGA | MDENNGLVTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HDVLDAQWMY | DNQRDESYLR | RVIQPLESLL | TTYKRIVVKD | SAVNAVCYGA | KLMIPGLLRF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAGIEVNEEV | VLMTTKGEAI | AIGIAQMSTV | ELSTCDHGVV | AKVKRCIMER | DLYPRRWGLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PVALEKKKLK | SAGKLDKYGR | ANEDTPAKWK | TEYKDYSAPE | EASAHAASES | TAKEDVAAAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TTEQDEAPSS | PQSKMDVDET | KEEKKRKRHE | GETAEERAER | KRKKKEKKEK | KERRKSKQEK |
| EDSDDSD |