O43100
Gene name |
cbf5 (swoC, AN8851) |
Protein name |
H/ACA ribonucleoprotein complex subunit CBF5 |
Names |
Prx, Thioredoxin peroxidase, TPx, Thioredoxin-dependent peroxiredoxin, Centromere-binding factor 5, H/ACA snoRNP protein CBF5, Small nucleolar RNP protein CBF5, rRNA pseudouridine synthase |
Species |
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
KEGG Pathway |
ani:AN8851.2 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O43100
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O43100-F1 | Predicted | AlphaFoldDB |
No variants for O43100
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O43100 | |||||
No associated diseases with O43100
5 regional properties for O43100
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PUA domain | 269 - 343 | IPR002478 |
| domain | Pseudouridine synthase II, N-terminal | 81 - 198 | IPR002501 |
| domain | Uncharacterised domain CHP00451 | 258 - 339 | IPR004521 |
| domain | Dyskerin-like | 19 - 77 | IPR012960 |
| domain | tRNA pseudouridylate synthase B, C-terminal | 199 - 265 | IPR032819 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| box H/ACA snoRNP complex | A box H/ACA RNP complex that is located in the nucleolus. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| pseudouridylate synthase activity | Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| anisotropic cell growth | The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell. |
| box H/ACA RNA 3'-end processing | Any process involved in forming the mature 3' end of a box H/ACA RNA molecule. |
| conidium formation | The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| establishment of cell polarity | The specification and formation of anisotropic intracellular organization or cell growth patterns. |
| mRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. |
| rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. |
| snoRNA guided rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. |
| snRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKEVDYTIK | PEATASNINT | EDWPLLLKNY | DKLMVRTGHF | TPIPAGSSPL | KRDLKSYINS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVINLDKPSN | PSSHEVVAWM | KRILRAEKTG | HSGTLDPKVT | GCLIVCIDRA | TRLVKSQQGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKEYVCVIRL | HDKIPGGEAQ | FKRALETLTG | ALFQRPPLIS | AVKRQLRIRT | IHESKLYEFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NERHLGVFWV | SCEAGTYIRT | LCVHLGLLLG | VGAHMQELRR | VRSGAMSENE | GMVTLHDVLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AQWLYDNQRD | ESYLRKVIKP | LESLLTTYKR | IVVKDSAVNA | VCYGAKLMIP | GLLRFEAGIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGEEVVLMTT | KGEAIAIGIA | QMSTVELSTC | DHGVVAKVKR | CIMERDLYPR | RWGLGPVALE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKKLKSSGKL | DKYGRANEAT | PAKWKSEYKD | YSAPDGDSSQ | QAVDVVAKEE | ASPKEEPSLE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ANESKMDIDD | AQDDEDKKKR | KRHEGETPEE | RAERKRKKKE | KKEKKERRKS | KQEKDDSDDS |
| D |