O43070

PR
Gene name
nbs1 (SPBC6B1.09c)
Protein name
DNA repair and telomere maintenance protein nbs1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC6B1.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

52-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for O43070

Entry ID Method Resolution Chain Position Source
3HUE X-ray 280 A A 1-330 PDB
3HUF X-ray 215 A A/B/C 1-321 PDB
3I0M X-ray 260 A A 1-324 PDB
3I0N X-ray 230 A A/B 1-324 PDB
4FBK X-ray 238 A A/B 474-531 PDB
4FBQ X-ray 250 A A/B 474-531 PDB
4FBW X-ray 220 A C/D 474-531 PDB
AF-O43070-F1 Predicted AlphaFoldDB

No variants for O43070

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O43070

No associated diseases with O43070

No regional properties for O43070

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O43070

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Chromosome, telomere
  • Localizes to DNA double-strand breaks (DSBs); recruited to DNA damage sites
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromosome, telomeric repeat region A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.
Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

2 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

12 GO annotations of biological process

Name Definition
DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
meiotic DNA double-strand break clipping The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP).
mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
protein localization to chromosome, telomeric region Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.
protein localization to site of double-strand break Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
telomere maintenance via recombination Any recombinational process that contributes to the maintenance of proper telomeric length.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MWIIEAEGDI LKGKSRILFP GTYIVGRNVS DDSSHIQVIS KSISKRHARF TILTPSEKDY
70 80 90 100 110 120
FTGGPCEFEV KDLDTKFGTK VNEKVVGQNG DSYKEKDLKI QLGKCPFTIN AYWRSMCIQF
130 140 150 160 170 180
DNPEMLSQWA SNLNLLGIPT GLRDSDATTH FVMNRQAGSS ITVGTMYAFL KKTVIIDDSY
190 200 210 220 230 240
LQYLSTVKES VIEDASLMPD ALECFKNIIK NNDQFPSSPE DCINSLEGFS CAMLNTSSES
250 260 270 280 290 300
HHLLELLGLR ISTFMSLGDI DKELISKTDF VVLNNAVYDS EKISFPEGIF CLTIEQLWKI
310 320 330 340 350 360
IIERNSRELI SKEIERLKYA TASNSTPQKI IQPQRHIQKN IVDDLFSVKK PLPCSPKSKR
370 380 390 400 410 420
VKTLENLSIM DFVQPKQMFG KEPEGYLSNQ SNNGSAQNKK SGDNSEKTKN SLKSSSKKSA
430 440 450 460 470 480
NTGSGQGKTK VEYVSYNSVD KGNSSPFKPL ELNVVGEKKA NAEVDSLPSE NVQESEDDKA
490 500 510 520 530 540
FEENRRLRNL GSVEYIRIMS SEKSNANSRH TSKYYSGRKN FKKFQKKASQ KAPLQAFLSL
550 560 570 580 590 600
SEHKKTEVFD QDDTDLEPVP RLMSKVESIP AGASSDKSGK SSISKKSSNS FKELSPKTNN
610
DEDDEFNDLK FHF