O42916

PR
Gene name
ale1 (lpt1, SPBC16A3.10)
Protein name
Lysophospholipid acyltransferase
Names
LPLAT, 1-acyl-sn-glycerol-3-phosphate acyltransferase, AGPAT, Lysophosphatidic acid acyltransferase, LPAAT, Lysophosphatidylcholine acyltransferase, LPCAT, Lysophosphatidylethanolamine acyltransferase, LPEAT
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC16A3.10
EC number
2.3.1.23: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

437-509 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42916

Entry ID Method Resolution Chain Position Source
AF-O42916-F1 Predicted AlphaFoldDB

No variants for O42916

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42916

No associated diseases with O42916

No regional properties for O42916

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O42916

Functions

Description
EC Number 2.3.1.23 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane; Multi-pass membrane protein
  • Microsome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
1-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.
1-acylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA.
acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

3 GO annotations of biological process

Name Definition
glycerophospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAYLIDIPFE YFSSFLGVHP DQLKLLFCFL SAYPFAGILK RLPSAPWIRN LFSISIGLFY
70 80 90 100 110 120
LIGVHHLYDG VLVLLFDALF TYFVAAFYRS SRMPWIIFIV ILGHTFSSHV IRYIYPSENT
130 140 150 160 170 180
DITASQMVLC MKLTAFAWSV YDGRLPSSEL SSYQKDRALR KIPNILYFLG YVFFFPSLLV
190 200 210 220 230 240
GPAFDYVDYE RFITLSMFKP LADPYEKQIT PHSLEPALGR CWRGLLWLIL FITGSSIYPL
250 260 270 280 290 300
KFLLTPKFAS SPILLKYGYV CITAFVARMK YYGAWELSDG ACILSGIGYN GLDSSKHPRW
310 320 330 340 350 360
DRVKNIDPIK FEFADNIKCA LEAWNMNTNK WLRNYVYLRV AKKGKRPGFK STLSTFTVSA
370 380 390 400 410 420
MWHGVSAGYY LTFVSAAFIQ TVAKYTRRHV RPFFLKPDME TPGPFKRVYD VIGMVATNLS
430 440 450 460 470 480
LSYLIISFLL LNLKESIHVW KELYFIVHIY ILIALAVFNS PIRSKLDNKI RSRVNSYKLK
490 500
SYEQSMKSTS DTDMLNMSVP KREDFENDE