O42869

PR
Gene name
SPAC3G9.05
Protein name
Uncharacterized protein C3G9.05
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3G9.05
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42869

Entry ID Method Resolution Chain Position Source
AF-O42869-F1 Predicted AlphaFoldDB

9 variants for O42869

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3175658_C_T 90 A>T No Jeffares_SNPs
I_3175508_C_T 140 A>T No Jeffares_SNPs
I_3175418_T_C 170 T>A No Jeffares_SNPs
I_3175090_G_A 279 A>V No Jeffares_SNPs
I_3175067_T_C 287 I>V No Jeffares_SNPs
I_3174882_T_G 348 E>D No Jeffares_SNPs
I_3174622_C_T 435 R>Q No Jeffares_SNPs
I_3174061_G_A 622 S>F No Jeffares_SNPs
I_3174026_C_T 634 A>T No Jeffares_SNPs

No associated diseases with O42869

2 regional properties for O42869

Type Name Position InterPro Accession
domain GIT, Spa2 homology (SHD) domain 33 - 63 IPR013724-1
domain GIT, Spa2 homology (SHD) domain 82 - 112 IPR013724-2

Functions

Description
EC Number
Subcellular Localization
  • Barrier septum
  • Cell tip
  • Localizes at the barrier septum and the cell tip
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
actomyosin contractile ring A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
cell cortex of growing cell tip Any cell cortex that is part of a growing cell tip.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
mitotic actomyosin contractile ring A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.
mitotic actomyosin contractile ring, intermediate layer The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer.

1 GO annotations of molecular function

Name Definition
MAP-kinase scaffold activity The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.

3 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns.
establishment or maintenance of cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQSIIIRQYR FLARYLEPEF VKDPALRNAN ARPREKLQRL SHIQFSELLT DVADELQRRI
70 80 90 100 110 120
NNDPKVRFLP PVDSYHPKRN HARQKLSSLA PTRLRDLCMD VFFEVQSRYS GALKEVSSNT
130 140 150 160 170 180
PPNMTRAASQ PPPQVQRLPA SAPKHDLYSS ANASSASLHP TEQRTTSSPT IPSYANRTHT
190 200 210 220 230 240
DSPTSLSHRL PNVPDTNALN TVQANNSSTS SLSQGAQTGI DSSSNYLSRI EMLESSLAKS
250 260 270 280 290 300
NSLLDSSKSE MEALKAKSIS DATKHKNEIF QLEEKLHEAS HEAEISIKKL NDAENRIKEL
310 320 330 340 350 360
ENNPTLSFNP ELEKNLKLMQ ELIVAESSKT QHIVELESCI DSLKAETERW KKVAINAKSA
370 380 390 400 410 420
KIDEDIRLFT MTTVPMKSIR ELISPNGFLD EQLYIRYFVE MNVFVASLRR DSPSQWMSTA
430 440 450 460 470 480
KDIALTLEAI VSSLREKSLL EELPDLGKKV DDLCSFTNSL MEQVRLAVIN GALLPIYHVD
490 500 510 520 530 540
ASACSISISL MDIAKTYGLT NTGKSSLSVG RNSLHPVDDL KALSVAKTLL SEKSKQFSET
550 560 570 580 590 600
NQKLLDAISS DSSSSTIQQR VHEDINVIRD TLFDVSSPLE LMRDRAAYAV IHNALQEMRR
610 620 630 640 650
YCMQLIEQEG HGENFGFTDN NSVPPLTDLA FSAAKCFKDI LRAIEDAEFS VQRTQFSTR