Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O42794
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O42794-F1 | Predicted | AlphaFoldDB |
No variants for O42794
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O42794 | |||||
No associated diseases with O42794
5 regional properties for O42794
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 145 - 275 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 330 - 394 | IPR000595-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 173 - 189 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 221 - 238 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 342 - 359 | IPR018488-3 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFPTYRPVQ | CSKLTDHELL | RIPHSPSLEP | LDYCIEPISY | LRRTVYDLHT | TVANRSSSRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLHKQPPVMF | KSPFGANANP | FGGASDGATV | GGNAMHQYNF | SRRTSVSAES | LKPSADTYDN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WTPPVHDKTN | EQLSRLKTAI | AGNFLFSHLD | DEQSAQILGA | LIEKPIPAKD | IKVISQGDAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYFYVVEKGS | FDVYVNEKGT | LQPGPEGMGE | KVGTIQAGGS | FGELALMYNA | PRAATVISAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGCTLWALDR | LTFRRILMES | TFLAAACTRT | SSEKFPCCRH | SHHMSAQKSP | TRWKLRSTPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRRLSRRETR | VTRFTCSRWR | GRCLPGEMAR | ESVKHYSKGD | FFGELALLND | APRAASIVAT |
| 370 | 380 | 390 | 400 | ||
| TDVKVASLGK | SAFQRLLGPV | EGIMRRTKYD | DIKTGVEEMD | PLQV |