O42783

PR
Gene name
treB
Protein name
Cytosolic neutral trehalase
Names
Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU04221
EC number
3.2.1.28: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42783

Entry ID Method Resolution Chain Position Source
AF-O42783-F1 Predicted AlphaFoldDB

No variants for O42783

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42783

No associated diseases with O42783

3 regional properties for O42783

Type Name Position InterPro Accession
domain Rhodanese-like domain 114 - 218 IPR001763
domain Rhodanase, C-terminal 221 - 287 IPR022111
domain tRNA uridine(34) hydroxylase, N-terminal 4 - 95 IPR040503

Functions

Description
EC Number 3.2.1.28 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
calcium ion binding Binding to a calcium ion (Ca2+).

1 GO annotations of biological process

Name Definition
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSQPSSGKG RGRNLSIDEY NVYDDAKTYY TTEDRHHNHR AGARTRTYSQ NSLFKQFERL
70 80 90 100 110 120
GLQKEPYRRG SHDESTIPQS RRFLIQVEPT LQSLQSQEDT DGNMQITIED NGPKVLSLRT
130 140 150 160 170 180
AASNGYNRFD IRGTYMLSNL LQELYLAKEY GRKQIILDEA RLNENPVNRL SRLIKDHFWE
190 200 210 220 230 240
GLTRRIDASS IEIAARDPKD WTDDPRPRIY IPRGAPEQHE YYTKVALDRP ELRLDVQYLP
250 260 270 280 290 300
EKITPEIVRD MNAKPGLLAV DMEEVVDPKT GEKTLRGRPF VVPGGRFNEL YGWDSYMESL
310 320 330 340 350 360
GLLVNDRVDL AKSMVQNFCF CIKHYGKILN ATRSYYLCRS QPPFLTDMTL RVYDKIKHEP
370 380 390 400 410 420
GALEFLRQSL LAAIKEYYSV WTAEPRLDPV TGLSRYRPEG LGVPPETEAG HFIHILEPYA
430 440 450 460 470 480
KKHNMSFDEF VYAYNHGEIK EPTLDDYFMH DRAVRESGHD TTYRFEGICA DLATIDLNSL
490 500 510 520 530 540
LFKYETDIAR TIRNVFHDKF EVPDDWLATN NPAASKLETS AMWDRRAKRR KLAIDKYLWN
550 560 570 580 590 600
EEAGMYFDYN TATRKQCNYE SATTFWALWA GVSNPKQAAA MVTKALPKLE AFGGLLSGTK
610 620 630 640 650 660
ESRGEIGLER PNRQWDYPYG WAPQQILAWT GLYRYGFNEE AERLAYKWLF MITKAFVDFN
670 680 690 700 710 720
GVVVEKYDVT RPIDPHRVDA EYGNQGLDFK GVAKEGFGWV NASYVYGLQI VNAHMRRALG
730 740
TLTPYETFMK AVEENRNKAL SELV