O42777

PR
Gene name
treB
Protein name
Cytosolic neutral trehalase
Names
Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN5635.2
EC number
3.2.1.28: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42777

Entry ID Method Resolution Chain Position Source
AF-O42777-F1 Predicted AlphaFoldDB

No variants for O42777

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42777

No associated diseases with O42777

3 regional properties for O42777

Type Name Position InterPro Accession
domain Rhodanese-like domain 114 - 218 IPR001763
domain Rhodanase, C-terminal 221 - 287 IPR022111
domain tRNA uridine(34) hydroxylase, N-terminal 4 - 95 IPR040503

Functions

Description
EC Number 3.2.1.28 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
calcium ion binding Binding to a calcium ion (Ca2+).
trehalase activity Catalysis of the hydrolysis of trehalose or a trehalose derivative.

3 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDSALPSNT SNGINGRTAH RRSSSGGDPF QHPDIYYGNP ESVERIKNRR RAFSSSLKSF
70 80 90 100 110 120
NRQDFHEMLG DRNTRRGSMD PTSGNPRKFL IDVDATLHSL LEREDSDRNM QITIEDVGPK
130 140 150 160 170 180
VFSLGTAASH GYNRFDVRGT YMLSNLLQEL TIAKDYGRKQ IVLDEERLSE NPVSRLSRLI
190 200 210 220 230 240
KNSFWNSLTR RIDGRNIEVA GRDPKDWTDD PRPRIYVPPG APEQLEYYRR IAEEKPELRL
250 260 270 280 290 300
DVQELAAEIT PEYVRDLNEK PGLLALAMEE KYDEKTGKTD FAGVPFVVPG GRFNELYGWD
310 320 330 340 350 360
SYMESLGLLA SNRVDLAKAM VINFCFCIKH YGKILNANRS YYLTRSQPPF LTDMALRVYD
370 380 390 400 410 420
RIQNEPGAMD FLRHAILAAI KEYYSVWMAE PRLDPVSGLS RYRSPGIGVP PETEASHFLH
430 440 450 460 470 480
LLTPYAEKHG MEFKEFVQAY NYGKVKEPEL DEYFMHDRAV RESGHDTSYR LERVCGNLAT
490 500 510 520 530 540
VDLNSLLYKY EVDIARVIRV YFKDKLEIPV EFRTPATKDI QSESSSVWDR RARRRKMRMD
550 560 570 580 590 600
TYLWDEEKGM YFDYDTVKQE RTNYESATTL WAMWAGLVTP RQASAMITKA LPRFEEFGGI
610 620 630 640 650 660
VSGTEESRGA VGLNRPTRQW DYPYGWAPQQ MLAWTGFARY GYQEEAERLA YKWLYMITKA
670 680 690 700 710 720
FVDFNGVVVE KYDVTRPIDP HRVDAEYGNQ GVDFKGAPRE GFGWVNASYV YGLEMLNAHQ
730 740 750
RRALGAVTPW ETYSKAVSAQ GSDTVLENRS E