O42667

PR
Gene name
ssm4 (SPAC27D7.13c, SPAC637.01c)
Protein name
Microtubule-associated protein ssm4
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC27D7.13c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42667

Entry ID Method Resolution Chain Position Source
AF-O42667-F1 Predicted AlphaFoldDB

22 variants for O42667

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4536564_T_A 41 K>N No Jeffares_SNPs
I_4536491_C_A 66 A>S No Jeffares_SNPs
I_4536368_A_T 107 S>T No Jeffares_SNPs
I_4536347_C_T 114 A>T No Jeffares_SNPs
I_4536338_A_T 117 L>M No Jeffares_SNPs
I_4536069_C_G 206 E>D No Jeffares_SNPs
I_4535974_A_G 238 L>S No Jeffares_SNPs
I_4535812_T_C 292 Y>C No Jeffares_SNPs
I_4535782_T_C 302 K>R No Jeffares_SNPs
I_4535714_C_T 325 V>I No Jeffares_SNPs
I_4535688_C_A 333 Q>H No Jeffares_SNPs
I_4535683_T_G 335 Q>P No Jeffares_SNPs
I_4535609_T_C 360 R>G No Jeffares_SNPs
I_4535601_T_A 362 L>F No Jeffares_SNPs
I_4535562_T_A 375 L>F No Jeffares_SNPs
I_4535126_T_C 521 M>V No Jeffares_SNPs
I_4534961_C_A 576 A>S No Jeffares_SNPs
I_4534960_G_A 576 A>V No Jeffares_SNPs
I_4534868_C_T 607 E>K No Jeffares_SNPs
I_4534843_G_A 615 T>I No Jeffares_SNPs
I_4534771_A_G 639 L>S No Jeffares_SNPs
I_4534756_T_A 644 D>V No Jeffares_SNPs

No associated diseases with O42667

2 regional properties for O42667

Type Name Position InterPro Accession
domain Protein kinase domain 8 - 306 IPR000719
binding_site Protein kinase, ATP binding site 14 - 37 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle
  • Mitotic spindle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
cell cortex of cell tip The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cortical microtubule plus-end The plus-end of a cortical microtubule.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
meiotic spindle pole body The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.
microtubule associated complex Any multimeric complex connected to a microtubule.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
microtubule plus-end The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
nucleus leading edge The area of a motile nucleus closest to the direction of movement.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle pole body The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.

1 GO annotations of molecular function

Name Definition
microtubule plus-end binding Binding to the plus end of a microtubule.

4 GO annotations of biological process

Name Definition
cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
dynein-driven meiotic oscillatory nuclear movement Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.
meiosis I The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.
nuclear migration involved in conjugation with cellular fusion The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYLSVGDEV LIRGELGIVR FAGSTDFESG IWLGVELLNG KGKNDGSVKG KRYFSCEKGK
70 80 90 100 110 120
GIFVRACSSN VMKRPSVVKS RKKGSENISN FMEKTKAIKQ KSRREPSKFE RSLARPLCIT
130 140 150 160 170 180
PIDSSTPTKT ATFYTSSTTE NLDELNFSTE ELSSFDTTLL NSDTSKLSGL DDSSFMEEEF
190 200 210 220 230 240
VWQVDNVLQE CEKKFTPHSK GSYLKENLKS ELRKGRLDEL MCENTALKEK IDKLNKELEK
250 260 270 280 290 300
VEPQLTFLRS KNSIEKPRNF RREKFLKKFL AMQKEIKYLR KRKLQIRKIP NYKYSDRSLN
310 320 330 340 350 360
SKTPKSQDNW TTQVTPSSLL GVSEVSKVLQ LKQVQVDITE LVKIPKNPFS EKLTISNVNR
370 380 390 400 410 420
YLNIVPGSLD LQFSLTNENF VHWNSTVYQE LLNLKSNNSS VDGVKTRRQL LEENALLSHK
430 440 450 460 470 480
VLKLTEEIQD LETLNQLNTE IEARQSEKLN EVQEETQRLS QLLISSQPAL TEVKHLKLCL
490 500 510 520 530 540
SDSQEELLQL NAKLEKANIV IDELNSAKLK LSKQVEEESS MKDDLTEMNQ RLKEQIESYE
550 560 570 580 590 600
NEVNSEITSR TLKEFETLKT QYEKNLCNLR EQLKTARMKL ADKYPQGDNT SENIDWLKHS
610 620 630 640 650 660
LRDSNTENSI PSPLTFACKE IRKLVADIKP VSVEKQLALN WKKDIERPSF HHNQQLFNYC
QLTDILSKKC