O42646

PR
Gene name
ubc6 (SPAC10F6.05c)
Protein name
Ubiquitin-conjugating enzyme E2 6
Names
E2 ubiquitin-conjugating enzyme 6, Ubiquitin carrier protein 6, Ubiquitin-protein ligase 6
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC10F6.05c
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

131-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42646

Entry ID Method Resolution Chain Position Source
AF-O42646-F1 Predicted AlphaFoldDB

2 variants for O42646

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1215288_C_T 173 A>T No Jeffares_SNPs
I_1215264_G_A 181 H>Y No Jeffares_SNPs

No associated diseases with O42646

1 regional properties for O42646

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 5 - 163 IPR000608

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

3 GO annotations of biological process

Name Definition
protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASKGAYKRL MKEYLALQKN PVELVDAKPA TENILEWHYI ITGPPDTPYE GGQYHGTLIF
70 80 90 100 110 120
PPDYPFKPPA IRMITPSGRF QTNTRLCLSF SDFHPKSWNP SWMVSTILVG LVSFMTSDEI
130 140 150 160 170 180
TTGGIVTSES TRRTYAKDTK RFNIMDNPKF LIMFPELIDK NREDIAKAAA EAALIEPQQI
190 200 210 220
HSTPVSSNEC KKNEPFNSKQ SWVKSRWSIA VLVFFALALA RFFGADS