O42617

PR
Gene name
PAPALPHA (PAP1)
Protein name
Poly(A) polymerase PAPalpha
Names
Polynucleotide adenylyltransferase alpha
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
EC number
2.7.7.19: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

491-558 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42617

Entry ID Method Resolution Chain Position Source
AF-O42617-F1 Predicted AlphaFoldDB

No variants for O42617

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42617

No associated diseases with O42617

3 regional properties for O42617

Type Name Position InterPro Accession
domain Polymerase, nucleotidyl transferase domain 76 - 158 IPR002934
domain Poly(A) polymerase, RNA-binding domain 352 - 526 IPR007010
domain Poly(A) polymerase, central domain 7 - 350 IPR007012

Functions

Description
EC Number 2.7.7.19 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule.
RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNTKTYGVTE PISTNGPTPK ENILNDALIQ ELKNRGSFES EQATKKRVEV LTLFQRLVQE
70 80 90 100 110 120
FVYTVSKSKN MSDSMAQDAG GKVFTFGSYR LGVYGPGSDI DTLVVVPKHV TRDDFFSVFA
130 140 150 160 170 180
DIIRKRPELE EIACVPDAYV PIIKLEFDGI SIDLIMARLN IPRVPLDLTL DDKNLLKNLD
190 200 210 220 230 240
EKDLRSLNGT RVTDEILQLV PKPTVFKHAL RCIKLWAQQR AVYGNIFGFP GGVAWAMLVA
250 260 270 280 290 300
RICQLYPNAV SSAIVEKFFN IYTKWNWPEP VLLKSIEDGP LQVRVWNPRL YPHDRLHRMP
310 320 330 340 350 360
VITPAYPSMC ATHNITSSTQ KVILAELSRG SSIMQEIHAG KKTWSDLFEK HSFFYKYKFY
370 380 390 400 410 420
LCVVAASIDS AEEHKKWSGF IESKLRQLVL KLEVAEGVEI AHPYVKDFSN TFILDDKNAE
430 440 450 460 470 480
DIINSYGTLS GEDFLRTLHS SDSDKDDEEF KKIRLTKYYI GLDLNLTKSS DGVRKLDIQY
490 500 510 520 530 540
PCAEFYSICK GSTSFTEGVN FIQIKNVKLH ELSNDVYEDG EERPKKSGKK RKKVIKEDGQ
550
KRVRNESPAS SASVNGSS