Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O42385
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O42385-F1 | Predicted | AlphaFoldDB |
No variants for O42385
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O42385 | |||||
No associated diseases with O42385
1 regional properties for O42385
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 62 - 401 | IPR017452 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-inhibiting serotonin receptor signaling pathway | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. |
| behavior | The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. |
| regulation of behavior | Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. |
| regulation of hormone secretion | Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. |
| regulation of vasoconstriction | Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. |
| serotonin receptor signaling pathway | The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. |
| spinal cord motor neuron differentiation | The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLRATSSND | SNATSGYSDT | AAVDWDEGEN | ATGSGSLPDP | ELSYQIITSL | FLGALILCSI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FGNSCVVAAI | ALERSLQNVA | NYLIGSLAVT | DLMVSVLVLP | MAALYQVLNK | WTLGQDICDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FIALDVLCCT | SSILHLCAIA | LDRYWAITDP | IDYVNKRTPR | RAAVLISVTW | LIGFSISIPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MLGWRSAEDR | ANPDACIISQ | DPGYTIYSTF | GAFYIPLILM | LVLYGRIFKA | ARFRIRKTVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTEKAKASDM | CLTLSPAVFH | KRANGDAVSA | EWKRGYKFKP | SSPCANGAVR | HGEEMESLEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IEVNSNSKTH | LPLPNTPQSS | SHENINEKTT | GTRRKIALAR | ERKTVKTLGI | IMGTFIFCWL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PFFIVALVLP | FCAENCYMPE | WLGAVINWLG | YSNSLLNPII | YAYFNKDFQS | AFKKILRCKF |
| HRH |