O42384

PR
Gene name
htr1a-B
Protein name
5-hydroxytryptamine receptor 1A-beta
Names
5-HT-1A-beta, 5-HT1A-beta, F1B, Serotonin receptor 1A-beta
Species
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KEGG Pathway
tru:101072291
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

201-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42384

Entry ID Method Resolution Chain Position Source
AF-O42384-F1 Predicted AlphaFoldDB

No variants for O42384

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42384

No associated diseases with O42384

5 regional properties for O42384

Type Name Position InterPro Accession
domain C2 domain 1 - 112 IPR000008
domain HECT domain 454 - 808 IPR000569
domain WW domain 223 - 256 IPR001202-1
domain WW domain 326 - 359 IPR001202-2
domain WW domain 386 - 419 IPR001202-3

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
G protein-coupled serotonin receptor activity Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.

6 GO annotations of biological process

Name Definition
adenylate cyclase-inhibiting serotonin receptor signaling pathway An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.
behavior The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
regulation of hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
regulation of vasoconstriction Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.
serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGTNNTTGW THFDSTSNRT SKSFDEEVKL SYQVVTSFLL GALILCSIFG NACVVAAIAL
70 80 90 100 110 120
ERSLQNVANY LIGSLAVTDL MVSVLVLPMA ALYQVLNRWT LGQIPCDIFI SLDMLCCTSS
130 140 150 160 170 180
ILHLCVIALD RYWAITEPID YMKKRTPRRA AVLISVTWLV GFSISIPPML IMRSQPSSMA
190 200 210 220 230 240
EDRANSKQCK ITQDPWYTIY STFGAFYIPL TLMLVLYGRI FKAARFRIRR TVRKTEKKKV
250 260 270 280 290 300
SDTCLALSPA MFHRKTPGDA HGKSWKRSVE PRPLPNVNGA VKHAGEGESL DIIEVQSNSR
310 320 330 340 350 360
CNLPLPNTPG TVPLFENRHE KATETKRKIA LARERKTVKT LGIIMGTFIL CWLPFFIVAL
370 380 390 400 410
VMPFCQESCF MPHWLKDVIN WLGYSNSLLN PIIYAYFNKD FQSAFKKIIK CHFCRA