O42127

PR
Gene name
fgfr3
Protein name
Fibroblast growth factor receptor 3
Names
FGFR-3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399347
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

624-649 (Activation loop from InterPro)

Target domain

462-751 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O42127

Entry ID Method Resolution Chain Position Source
AF-O42127-F1 Predicted AlphaFoldDB

No variants for O42127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42127

No associated diseases with O42127

15 regional properties for O42127

Type Name Position InterPro Accession
domain Protein kinase domain 462 - 751 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 462 - 738 IPR001245
domain Immunoglobulin subtype 2 43 - 105 IPR003598-1
domain Immunoglobulin subtype 2 156 - 224 IPR003598-2
domain Immunoglobulin subtype 2 255 - 333 IPR003598-3
domain Immunoglobulin subtype 37 - 115 IPR003599-1
domain Immunoglobulin subtype 150 - 235 IPR003599-2
domain Immunoglobulin subtype 249 - 344 IPR003599-3
domain Immunoglobulin-like domain 27 - 115 IPR007110-1
domain Immunoglobulin-like domain 140 - 233 IPR007110-2
domain Immunoglobulin-like domain 242 - 330 IPR007110-3
active_site Tyrosine-protein kinase, active site 603 - 615 IPR008266
domain Immunoglobulin I-set 154 - 234 IPR013098
binding_site Protein kinase, ATP binding site 468 - 498 IPR017441
domain Tyrosine-protein kinase, catalytic domain 462 - 738 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

2 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSVNGVPAA RLPVTLPGED RASRKAPDYL MVEQPPFDEL MYTIGETIEL SCAAEDASTT
70 80 90 100 110 120
TKWCKDGIGI VPNNRTSTRQ GLLKIINVSS DDSGIYSCRL WHSTEILRNF TIRVTDLPSS
130 140 150 160 170 180
GDDEDDDDDD DDETEDREPP RWTQPERMEK KLIAVPAANT IRFRCPAAGN PTPTIHWLKN
190 200 210 220 230 240
GKEFRGEHRI GGIKLRHQQW SLVMESVVPS DKGNYTCVVE NKYGSIRQTY QLDVLERSSH
250 260 270 280 290 300
RPILQAGLPG NQTVVLGSDV EFHCKVYSDA QPHIQWLKHV EVNGSKYGPD GDPYVSVLQS
310 320 330 340 350 360
FINGTEVDST LSLKNVTETN EGQYVCRANN FIGVAEASFW LHIYKPAPAE PVEKALTTSS
370 380 390 400 410 420
SSITVLIVVT STIVFILLVI IVITHLMKVP SKKSMTAPPV HKVSKFPLKR QQVSLESNSS
430 440 450 460 470 480
MNSNTPLVRI THLSSSDGTM LANVSELGLP LDPKWELLRS RLTLGKPLGE GCFGQVVMAE
490 500 510 520 530 540
AIGIDKERPN KPATVAVKML KDDATDKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQDGP
550 560 570 580 590 600
LYVLVEYASK GSLREYLKAR RPPGMDYSFD ACKIPAEQLT FKDLVSCAYQ VARGMEYLAS
610 620 630 640 650 660
QKCIHRDLAA RNVLVTDDNV MKIADFGLAR DIHNIDYYKK TTNGRLPVKW MAPEALFDRI
670 680 690 700 710 720
YTHHSDVWSY GVLLWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPANCT HELYMIMREC
730 740 750 760 770 780
WHAVPSQRPA FKQLVEDLDR VLTVTSTNEY LDLSVAFEQY SPPSQDSHST CSSGDDSVFA
790 800
HDILPDEPCL PKHQQHNGAI PT