O42043

PR
Gene name
ERVK-18
Protein name
Endogenous retrovirus group K member 18 Env polyprotein
Names
Envelope polyprotein, HERV-K(C1a) envelope protein, HERV-K110 envelope protein, HERV-K18 envelope protein, HERV-K18 superantigen, HERV-K_1q23.3 provirus ancestral Env polyprotein, IDDMK1,2 22 envelope protein, IDDMK1,2 22 superantigen
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-214 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42043

Entry ID Method Resolution Chain Position Source
AF-O42043-F1 Predicted AlphaFoldDB

5 variants for O42043

Variant ID(s) Position Change Description Diseaes Association Provenance
VAR_018642 97 C>Y allele HERV-K18.1 and allele HERV-K18.3 [UniProt] No UniProt
VAR_018643 155 A>del allele HERV-K18.1 [UniProt] No UniProt
VAR_018644 272 V>I allele HERV-K18.3 [UniProt] No UniProt
VAR_018645 348 V>I allele HERV-K18.3 [UniProt] No UniProt
VAR_018646 534 V>I allele HERV-K18.3 [UniProt] No UniProt

No associated diseases with O42043

1 regional properties for O42043

Type Name Position InterPro Accession
domain AP2/ERF domain 19 - 83 IPR001471

Functions

Description
EC Number
Subcellular Localization
  • [Transmembrane protein]: Cell membrane ; Single-pass type I membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVTPVTWMDN PIEVYVNDSV WVPGPTDDRC PAKPEEEGMM INISIGYHYP PICLGRAPGC
70 80 90 100 110 120
LMPAVQNWLV EVPTVSPNSR FTYHMVSGMS LRPRVNCLQD FSYQRSLKFR PKGKTCPKEI
130 140 150 160 170 180
PKGSKNTEVL VWEECVANSV VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV
190 200 210 220 230 240
DSDLTESLDK HKHKKLQSFY LWEWEEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI
250 260 270 280 290 300
WSGNQTLETR YRKPFYTIDL NSILTVPLQS CVKPPYMLVV GNIVIKPASQ TITCENCRLF
310 320 330 340 350 360
TCIDSTFNWQ HRILLVRARE GMWIPVSTDR PWEASPSIHI LTEILKGVLN RSKRFIFTLI
370 380 390 400 410 420
AVIMGLIAVT ATAAVAGVAL HSSVQSVNFV NYWQKNSTRL WNSQSSIDQK LASQINDLRQ
430 440 450 460 470 480
TVIWMGDRLM TLEHHFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS
490 500 510 520 530 540
KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWIK TIRSTMIINL ILIVVCLFCL
550
LLVCRCTQQL RRDSDIENGP