O40977

PR
Gene name
ORF2a
Protein name
RNA-directed RNA polymerase 2a
Names
protein 2a
Species
Cucumber mosaic virus (strain NT9) (CMV)
KEGG Pathway
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

737-853 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for O40977

Entry ID Method Resolution Chain Position Source

No variants for O40977

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O40977

No associated diseases with O40977

3 regional properties for O40977

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 309 - 741 IPR001788
domain RNA-directed RNA polymerase, catalytic domain 511 - 624 IPR007094
domain RNA-dependent RNA polymerase, bromovirus 310 - 672 IPR047309

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFSAPTFSL ANLLNGSYGV DTPEEVERVR SEQREEAAAA CRNYRPLPAV DVSESVTEDA
70 80 90 100 110 120
HSLRTPDGAP SEEVSVEFVT YGAEDYLEKS DDELSVAFET MVKPMRIGQL WCPAFNKCSF
130 140 150 160 170 180
ISSIAMARAL LLAPRTSHRT MKGFEDLVAA IYTKSDFYYD EECEADDIQI DVSSRDVPGY
190 200 210 220 230 240
SFEPWSRTSG FEPPPICEAC DMIMYQCPCF DFNALKKSCA ERTFADDYVI EGLDGVVDNA
250 260 270 280 290 300
TLLSNLGPFL VPVKCQYEKC PTPTVAIPPS LNRATDRVDI NLVQSICDST LPTHSNYDDS
310 320 330 340 350 360
FHQVFVESAD YSIDLDHVRL RQSDLIAKIP DSGHMIPVLS TGSGHKRVGT TKEVLTAIKK
370 380 390 400 410 420
RNADVPELGD SVNLSRLSKA VAERFFISYI NGNSLASSNF VNVVSNFHDY MEKWKSSGLS
430 440 450 460 470 480
YDDLPDLHAE NLQFYDHMIK SDVKPVVSDT LNIDRPVPAT ITYHKKGITS QFSPLFTALF
490 500 510 520 530 540
ERFQRCLRER IILPVGKISS LEMAGFDVKN KHCLEIDLSK FDKSQGEFHL MIQEHILNGL
550 560 570 580 590 600
GCPAPITKWW CDFHRFSYIR DRRAGVGMPI SFQRRTGDAF TYFGNTIVTM AEFAWCYDTD
610 620 630 640 650 660
QFEKLLFSGD DSLGFSVLPP VGDPSKFTTL FNMEAKVMEP AVPYICSKFL LSDEFGNTFS
670 680 690 700 710 720
VPDPLREVQR LGTKKIPYSD NDEFLFAHFM SFVDRLKFLD RMTQSCIDQL SLFFELKYRK
730 740 750 760 770 780
SGAEAALMLG AFKKYTANFQ SYKELYYSDR RQCELINSFS CVELRIERSS STKQRKKKDG
790 800 810 820 830 840
IERRRSDKRR TPTGSYGGGE KTETKVSHEE STGTRSQKSQ REGAFKSQIV PLPTILSGGW
850
SGTDRAPPCE HGGIIRI