Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O36432
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6QWL | EM | 410 A | E | 1-726 | PDB |
No variants for O36432
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O36432 | |||||
No associated diseases with O36432
No regional properties for O36432
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O36432 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell cytoplasm | The cytoplasm of a host cell. |
| host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| metal ion binding | Binding to a metal ion. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cap snatching | A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs. |
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity. |
| viral RNA genome replication | The replication of a viral RNA genome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTFITRNFQ | TTIIQKAKNT | MAEFSEDPEL | QPAMLFNICV | HLEVCYVISD | MNFLDEEGKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YTALEGQGKE | QNLRPQYEVI | EGMPRTIAWM | VQRSLAQEHG | IETPKYLADL | FDYKTKRFIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGITKGLADD | YFWKKKEKLG | NSMELMIFSY | NQDYSLSNES | SLDEEGKGRV | LSRLTELQAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSLKNLWQVL | IGEEDVEKGI | DFKLGQTISR | LRDISVPAGF | SNFEGMRSYI | DNIDPKGAIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNLARMSPLV | SATPKKLKWE | DLRPIGPHIY | NHELPEVPYN | AFLLMSDELG | LANMTEGKSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPKTLAKECL | EKYSTLRDQT | DPILIMKSEK | ANENFLWKLW | RDCVNTISNE | EMSNELQKTN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YAKWATGDGL | TYQKIMKEVA | IDDETMCQEE | PKIPNKCRVA | AWVQTEMNLL | STLTSKRALD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPEIGPDVAP | VEHVGSERRK | YFVNEINYCK | ASTVMMKYVL | FHTSLLNESN | ASMGKYKVIP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ITNRVVNEKG | ESFDMLYGLA | VKGQSHLRGD | TDVVTVVTFE | FSSTDPRVDS | GKWPKYTVFR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IGSLFVSGRE | KSVYLYCRVN | GTNKIQMKWG | MEARRCLLQS | MQQMEAIVEQ | ESSIQGYDMT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KACFKGDRVN | SPKTFSIGTQ | EGKLVKGSFG | KALRVIFTKC | LMHYVFGNAQ | LEGFSAESRR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLLLIQALKD | RKGPWVFDLE | GMYSGIEECI | SNNPWVIQSA | YWFNEWLGFE | KEGSKVLESV |
| DEIMDE |