O36016

PR
Gene name
rrd1 (SPAC4F10.04)
Protein name
Serine/threonine-protein phosphatase 2A activator 1
Names
Peptidyl-prolyl cis-trans isomerase PTPA-1, PPIase PTPA-1, Rotamase PTPA-1, Phosphotyrosyl phosphatase activator 1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC4F10.04
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O36016

Entry ID Method Resolution Chain Position Source
AF-O36016-F1 Predicted AlphaFoldDB

2 variants for O36016

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4837249_A_G 285 I>M No Jeffares_SNPs
I_4837247_A_G 285 I>V No Jeffares_SNPs

No associated diseases with O36016

No regional properties for O36016

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O36016

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

2 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
protein tyrosine phosphatase activator activity Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.

2 GO annotations of biological process

Name Definition
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVVDEKTIL ELENERFDES SQFKTPEKLI VEASDMTAFR QSKAYYRIFD FLQRLNIASV
70 80 90 100 110 120
GVNDYHVEYS TRVEKLVRIL CRVKEITKTV PPASGRHRFG NPAFRIWHEK LRDSASQIMD
130 140 150 160 170 180
IIIPDSLSKA KVELLDYFLG SFGNSQRIDF GTGHELNFLG FIKGLDLLGL LDAADYKAIA
190 200 210 220 230 240
LYITHVYLEV CRELVQTYRL EPAGSHGVWG LDDHFFIPYI FGSAQLADKA SSSIIKPDAI
250 260 270 280 290 300
LNKKIVDEKA NSNLYFSAIK FINVMKKGPF YEHSPILYDI TAVPIWSKVN QGLIKMYDVE
310 320
VLSKYPVVQH FHFGNLFPFN PLVAK