O35893

PR
Gene name
Sp100
Protein name
Nuclear autoantigen Sp-100
Names
Nuclear dot-associated Sp100 protein, Speckled 100 kDa
Species
Mus caroli (Ryukyu mouse) (Ricefield mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35893

Entry ID Method Resolution Chain Position Source
AF-O35893-F1 Predicted AlphaFoldDB

No variants for O35893

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O35893

No associated diseases with O35893

2 regional properties for O35893

Type Name Position InterPro Accession
domain SAND domain 378 - 459 IPR000770
domain HSR domain 6 - 121 IPR004865

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus, PML body
  • Nucleus, nuclear body
  • Cytoplasm
  • Accumulates in the cytoplasm upon FAS activation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.

7 GO annotations of biological process

Name Definition
negative regulation of endothelial cell migration Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
negative regulation of protein export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of extrinsic apoptotic signaling pathway via death domain receptors Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
regulation of Fas signaling pathway Any process that modulates the frequency, rate or extent of Fas signaling pathway.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDSNASPRM STEHENTEMH PFEYMFKHFK TQKVAISNAI RSTFPFLESL RDREFITGKM
70 80 90 100 110 120
YEDLIDSCRS LVPVDKVIYK ALDELEKKFD VTVLWELFNE VNMEKYPDLN PIRRSFECVF
130 140 150 160 170 180
PNELSFQGID RGNPNSQLSL EQGPSASYSQ GSLNGSSLDL SSSEGWRSND RRNSNLMQAN
190 200 210 220 230 240
QTENHQLAES PGHLDSCELQ VQLNNGDATP ESYSLLPQHE ERAVQLNNEF QINPCFVQLI
250 260 270 280 290 300
DVKKENSSFS LAGNQQTRAR TNQNEDSEVI ELSSGDSDDG ENFSEATTTI PSQPAPAYSR
310 320 330 340 350 360
TPPTLRTDRR GDTSDTESSI IIRRRKRTGR KKRERLGSYL IRNIKIPMKT SWKTAVLARS
370 380 390 400 410 420
ANTSSQRRRK RGPRIPREEN ADFGGAELPA VCGNVQGFLN KEKFKQGIYV RSIRSETGRL
430 440 450 460 470 480
FTPMDFEIEG NCEKAKNWRQ TIRCKGWTLR ELIQKGVLQD PPRKKKENPR NPRQMKRQVN
AL