O35841
Gene name |
Api5 |
Protein name |
Apoptosis inhibitor 5 |
Names |
API-5, AAC-11 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11800 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35841
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35841-F1 | Predicted | AlphaFoldDB |
10 variants for O35841
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388573678 | 29 | Q>E | No | EVA | |
| rs3388573606 | 119 | N>K | No | EVA | |
| rs225470619 | 226 | A>T | No | EVA | |
| rs3413073269 | 269 | N>I | No | EVA | |
| rs3388567172 | 308 | R>* | No | EVA | |
| rs3388575589 | 315 | L>F | No | EVA | |
| rs3391889722 | 452 | G>W | No | EVA | |
| rs3388569622 | 454 | K>R | No | EVA | |
| rs3412114014 | 469 | S>F | No | EVA | |
| rs3388571328 | 471 | G>E | No | EVA |
No associated diseases with O35841
1 regional properties for O35841
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, GATA-type | 155 - 204 | IPR000679 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| fibroblast growth factor binding | Binding to a fibroblast growth factor. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| fibroblast apoptotic process | Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of fibroblast apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZZ5 | API5 | Apoptosis inhibitor 5 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTVEELYRN | YGILADATEQ | VGQHKDAYQV | ILDGVKGGTK | EKRLAAQFIP | KFFKHFPELA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSAINAQLDL | CEDEDVSIRR | QAIKELPQFA | TGENLPRVAD | ILTQLLQTDD | SAEFNLVNNA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLSIFKMDAK | GTLGGLFSQI | LQGEDIVRER | AIKFLSTKLK | TLPDEVLTKE | VEELILTESK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVLEDVTGEE | FVLFMKILSG | LKSLQTVSGR | QQLVELVAEQ | ADLEQAFSPS | DPDCVDRLLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTRQAVPLFS | KNVHSTRFVT | YFCEQVLPNL | STLTTPVEGL | DIQLEVLKLL | AEMSSFCGDM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKLETNLRKL | FDKLLEYMPL | PPEEAENGEN | AGNEEPKLQF | SYVECLLYSF | HQLGRKLPDF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTAKLNAEKL | KDFKIRLQYF | ARGLQVYIRQ | LRLALQGKTG | EALKTEENKI | KVVALKITNN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| INVLIKDLFH | IPPSYKSTVT | LSWKPVQKVE | IGQKRTSEDT | SSGSPPKKSP | GGPKRDARQI |
| 490 | 500 | ||||
| YNPPSGKYSS | NLSNFNYERS | LQGK |