O35817
Gene name |
Akap14 (Takap80) |
Protein name |
A-kinase anchor protein 14 |
Names |
AKAP-14, TAKAP-1.2, Testis-specific A-kinase-anchoring protein TAKAP-80 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:60332 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35817
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35817-F1 | Predicted | AlphaFoldDB |
No variants for O35817
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O35817 | |||||
No associated diseases with O35817
No regional properties for O35817
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O35817 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| axoneme | The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| sperm fibrous sheath | A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase A binding | Binding to a protein kinase A. |
| protein kinase A regulatory subunit binding | Binding to one or both of the regulatory subunits of protein kinase A. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNNKKKPPNQ | KAKTVENTST | AKAKKPEAPE | PKNVTEPKDS | KAVEDPKKSV | TNQKEKKTVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIADPKDKKS | VTEPKEKKTV | TISDPKDKKP | VIEKDKRTVT | FVTDVKDKRI | VTDTKENRIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIDTKEKGPV | VPEVKEKKVQ | LIDPKEKVVA | PVAPVAPVAH | AAQVPHAAQV | PHAVQVPHAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVAHAAPVAH | TAQVSHAAPV | APSLPVVPPA | PVVPLAPVVP | PAPVAHTEPV | AHAVPFAPPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVAPPASVAP | PVPDAPVALV | APVAPQVKQK | IRVSEVKRKK | EVPPRVPQLK | EMKVVLFTPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IKEKKVVSEI | KEKTQVIDGK | EKLIVPDVKE | KKPAVVEKKD | ERMNEIARTV | VEGVLAASVQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FVEEARNPIK | NIKWLTHGEF | TAEKGRKQIE | KFVSTWEFQN | RWVYYADFIE | KKDLIHSFHY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYRVRWSAPT | AVRPMARVSA | NAYFTIKFNK | SKPADMPVDV | SYIFENSELL | QRPGKIRFRE |
| 490 | 500 | ||||
| QWLRDITETK | HILLESIPFK | VV |