O35674
PR
Gene name |
Adam19 (Mltnb) |
Protein name |
Disintegrin and metalloproteinase domain-containing protein 19 |
Names |
ADAM 19, Meltrin-beta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11492 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35674
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35674-F1 | Predicted | AlphaFoldDB |
54 variants for O35674
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs213145188 | 20 | H>P | No | EVA | |
| rs3389126888 | 23 | L>M | No | EVA | |
| rs3400948273 | 100 | S>G | No | EVA | |
| rs3401811353 | 118 | G>V | No | EVA | |
| rs3401953221 | 119 | T>P | No | EVA | |
| rs233745563 | 122 | D>G | No | EVA | |
| rs243660825 | 122 | D>H | No | EVA | |
| rs243660825 | 122 | D>N | No | EVA | |
| rs3402251105 | 127 | S>R | No | EVA | |
| rs3389145096 | 146 | L>H | No | EVA | |
| rs3389160067 | 147 | S>R | No | EVA | |
| rs26981977 | 149 | I>V | No | EVA | |
| rs3389150227 | 165 | S>P | No | EVA | |
| rs3389160020 | 179 | H>L | No | EVA | |
| rs3389126929 | 195 | T>I | No | EVA | |
| rs3389150148 | 252 | L>P | No | EVA | |
| rs3389163361 | 265 | T>R | No | EVA | |
| rs3389157106 | 267 | G>W | No | EVA | |
| rs3402168837 | 351 | N>S | No | EVA | |
| rs3402147056 | 377 | T>I | No | EVA | |
| rs3389145109 | 426 | E>G | No | EVA | |
| rs3389150232 | 440 | K>N | No | EVA | |
| rs3389115326 | 510 | G>S | No | EVA | |
| rs3389147100 | 530 | W>C | No | EVA | |
| rs3389115317 | 538 | L>F | No | EVA | |
| rs3389122659 | 556 | G>D | No | EVA | |
| rs3389145089 | 594 | D>V | No | EVA | |
| rs3389115289 | 628 | G>A | No | EVA | |
| rs3389163365 | 646 | Q>K | No | EVA | |
| rs3389138824 | 647 | C>Y | No | EVA | |
| rs3389126948 | 654 | E>A | No | EVA | |
| rs250255835 | 681 | S>A | No | EVA | |
| rs3389090006 | 701 | P>L | No | EVA | |
| rs3389126890 | 711 | V>M | No | EVA | |
| rs234994280 | 739 | A>S | No | EVA | |
| rs3389163399 | 750 | C>F | No | EVA | |
| rs3389145054 | 768 | K>N | No | EVA | |
| rs3389160040 | 776 | R>L | No | EVA | |
| rs3389126936 | 779 | T>A | No | EVA | |
| rs3402273307 | 790 | H>P | No | EVA | |
| rs3402440041 | 794 | R>QWCR* | No | EVA | |
| rs3389152211 | 795 | P>T | No | EVA | |
| rs26967449 | 810 | P>L | No | EVA | |
| rs3389126921 | 811 | A>T | No | EVA | |
| rs3389150410 | 816 | A>P | No | EVA | |
| rs226302758 | 826 | R>Q | No | EVA | |
| rs3402645599 | 855 | S>P | No | EVA | |
| rs3389160089 | 856 | R>K | No | EVA | |
| rs3389089979 | 858 | R>P | No | EVA | |
| rs3389157117 | 861 | Q>* | No | EVA | |
| rs249044400 | 875 | G>S | No | EVA | |
| rs246257501 | 881 | T>S | No | EVA | |
| rs232288941 | 916 | I>T | No | EVA | |
| rs3389150205 | 919 | K>* | No | EVA |
No associated diseases with O35674
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| metalloendopeptidase activity involved in amyloid precursor protein catabolic process | Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| amyloid precursor protein catabolic process | The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
| placenta development | The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. |
| positive regulation of cell-cell adhesion mediated by cadherin | Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O43506 | ADAM20 | Disintegrin and metalloproteinase domain-containing protein 20 | Homo sapiens (Human) | PR |
| Q99965 | ADAM2 | Disintegrin and metalloproteinase domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q9UKF2 | ADAM30 | Disintegrin and metalloproteinase domain-containing protein 30 | Homo sapiens (Human) | PR |
| Q8TC27 | ADAM32 | Disintegrin and metalloproteinase domain-containing protein 32 | Homo sapiens (Human) | PR |
| Q9H013 | ADAM19 | Disintegrin and metalloproteinase domain-containing protein 19 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGRAGVARF | CLLALALQLH | WPLAACEPGW | TTRGSQEGSP | PLQHELIIPQ | WRTSESPGRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHPLRAELRV | MAEGRELILD | LEKNEHLFAP | AYTETCYTAS | GNPQTSTLKS | EDHCFYHGTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RDVDESSVTL | STCRGIRGLI | IVRSNLSYII | EPVPNSDSQH | RIYRSEHLTL | PPGNCGFEHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPTSKDWALQ | FTHQTKKQPR | RMKREDLHSM | KYVELYLVAD | YAEFQKNRHD | QDATKRKLME |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IANYVDKFYR | SLNIRIALVG | LEVWTHGDKC | EVSENPYSTL | WSFLSWRRKL | LAQKSHDNAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LITGRSFQGT | TIGLAPLMAM | CSVYQSGGVS | MDHSENAIGV | ASTVAHEIGH | NFGMSHDSAH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CCSASAADGG | CIMAAATGHP | FPKVFSWCNR | KELDRYLQTG | GGMCLSNMPD | TRTLYGGRRC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GNGYLEDGEE | CDCGEEEECK | NPCCNASNCT | LKEGAECAHG | SCCHQCKLVA | PGTQCREQVR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QCDLPEFCTG | KSPHCPTNYY | QMDGTPCEGG | QAYCYNGMCL | TYQEQCQQLW | GPGARPALDL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CFERVNAAGD | TYGNCGKGLN | GQYRKCSPRD | AKCGKIQCQS | TQARPLESNA | VSIDTTITLN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GRRIHCRGTH | VYRGPEEEEG | EGDMLDPGLV | MTGTKCGHNH | ICFEGQCRNT | SFFETEGCGK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KCNGHGVCNN | NKNCHCFPGW | SPPFCNTPGD | GGSVDSGPLP | PKSVGPVIAG | VFSALFVLAV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LVLLCHCYRQ | SHKLGKPSAL | PFKLRHQFSC | PFRVSQSGGT | GHANPTFKLQ | TPQGKRKVTN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TPESLRKPSH | PPPRPPPDYL | RVESPPAPLP | AHLNRAAGSS | PEAGARIERK | ESARRPPPSR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PMPPAPNCLL | SQDFSRPRPP | QKALPANPVP | GQRTGPRSGG | TSLLQPPTSG | PQPPRPPAVP |
| 910 | |||||
| VPKLPEYRSQ | RVGAIISSKI |