O35601
Gene name |
Fyb1 (Fyb) |
Protein name |
FYN-binding protein 1 |
Names |
Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:23880 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35601
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35601-F1 | Predicted | AlphaFoldDB |
38 variants for O35601
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389331148 | 36 | K>N | No | EVA | |
| rs243785643 | 47 | P>L | No | EVA | |
| rs3389349605 | 48 | P>H | No | EVA | |
| rs3389352991 | 103 | P>T | No | EVA | |
| rs3389358118 | 116 | K>R | No | EVA | |
| rs3389353185 | 120 | L>F | No | EVA | |
| rs3389322205 | 143 | E>G | No | EVA | |
| rs3389331235 | 169 | S>T | No | EVA | |
| rs3389349598 | 179 | M>T | No | EVA | |
| rs3389366445 | 187 | S>P | No | EVA | |
| rs3389352986 | 203 | S>I | No | EVA | |
| rs3389322240 | 225 | Q>H | No | EVA | |
| rs3389366433 | 235 | F>L | No | EVA | |
| rs48287400 | 238 | P>A | No | EVA | |
| rs3389304505 | 239 | K>M | No | EVA | |
| rs221896081 | 263 | A>V | No | EVA | |
| rs246284576 | 267 | S>N | No | EVA | |
| rs3389340720 | 328 | A>V | No | EVA | |
| rs225132171 | 341 | L>V | No | EVA | |
| rs3389346905 | 389 | A>V | No | EVA | |
| rs3389322180 | 409 | P>L | No | EVA | |
| rs3389353024 | 424 | D>E | No | EVA | |
| rs3389271883 | 433 | S>F | No | EVA | |
| rs3389314766 | 448 | E>K | No | EVA | |
| rs3389366377 | 512 | G>* | No | EVA | |
| rs3389347937 | 520 | K>R | No | EVA | |
| rs3389271930 | 557 | I>T | No | EVA | |
| rs254021730 | 582 | D>E | No | EVA | |
| rs211986113 | 590 | Q>H | No | EVA | |
| rs3389346925 | 685 | E>D | No | EVA | |
| rs3389322237 | 701 | E>D | No | EVA | |
| rs3389366383 | 739 | G>D | No | EVA | |
| rs3389352960 | 747 | T>S | No | EVA | |
| rs3389304534 | 752 | S>P | No | EVA | |
| rs3405502571 | 774 | I>T | No | EVA | |
| rs3405028560 | 776 | S>T | No | EVA | |
| rs3389322172 | 797 | S>N | No | EVA | |
| rs3405642983 | 806 | I>F | No | EVA |
No associated diseases with O35601
4 regional properties for O35601
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 499 - 560 | IPR001452-1 |
| domain | SH3 domain | 736 - 804 | IPR001452-2 |
| domain | Helically-extended SH3 domain | 731 - 819 | IPR029294 |
| domain | FYB, helically extended SH3 domain | 730 - 801 | IPR035540 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
| protein-containing complex binding | Binding to a macromolecular complex. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| integrin-mediated signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| T cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5VWT5 | FYB2 | FYN-binding protein 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKFNTGSNP | TEEAATSSRP | FKVAGQSSPS | GIQSRKNLFD | NQGNASPPAG | PSSMPKFGTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPPLAAKPTY | EEKPEKEPKP | PFLKPTGGSP | RFGTQPNSVS | RDPEVKVGFL | KPVSPKPTSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TKEDSKPVVL | RPPGNKLHNL | NQESDLKTPG | PKPGPAPPVP | ENELKPGFSK | VAGAKSKFMP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAQDTDSKPR | FPRHTFGQKP | SLSTEDSQEE | NTSKNVPVQK | GSPVQLGAKS | KGAPFKPPKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPEDKDHGAP | SSPFPGVVLK | PAASRGSPGL | SKNFEEKKED | RKTDLAKNIF | LNKLNQEEPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFPKAPSKLT | AGTPWGQSQE | KEGDKNSATP | KQKALPPLSV | LGPPPPKPNR | PPNVDLTRFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KADSANSATK | SQTPYSTTSL | PPPPPTHPAS | QPPLPASHPA | HPPVPSLPPR | NIKPPLDLKH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PINDENQDGV | MHSDGTGNLE | EEQESEGETY | EDIDSSKERD | KKREKEEKKR | LELERKEQKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REKKEQELKK | KFKLTGPIQV | IHHAKACCDV | KGGKNELSFK | QGEDIEIIRI | TDNPEGKWLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RTARGSYGYI | KTTAVEIDYD | SLKRKKNSLN | AVPPRLVEDD | QDVYDDVAEQ | DAPNSHGQSG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGGMFPPPPT | DDEIYDGIEE | EDDDDGSVPQ | VDEKTNAWSW | GILKMLKGKD | DRKKSIREKP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KVSESDNNEG | SSLPSQHKQL | DVGEEVYDDV | DASDFPPPPA | EMSQGMSVGR | AKTEEKDPKK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LKKQEKEEKD | LRKKFKYDGE | IRVLYSTKVA | SSLTSKKWGA | RDLQIKPGES | LEVIQSTDDT |
| 790 | 800 | 810 | |||
| KVLCRNEEGK | YGYVLRSYLV | DNDGEIYDDI | ADGCIYDND |