AiPD: Autoinhibited Protein Database

Gene name	Pld3 (Sam9)
Protein name	5'-3' exonuclease PLD3
Names	Choline phosphatase 3, Phosphatidylcholine-hydrolyzing phospholipase D3, Phospholipase D3, PLD 3, Schwannoma-associated protein 9, SAM-9
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:18807
EC number	3.1.16.1: Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-48 (Predicted disordered autoinhibitory region) PR

1-48 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O35405-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388872349	30	K>M	No	EVA
rs3397860537	51	G>S	No	EVA
rs3397627196	52	A>T	No	EVA
rs3397762498	53	L>M	No	EVA
rs3397716351	53	L>R	No	EVA
rs3397667029	54	M>R	No	EVA
rs3388884778	77	C>Y	No	EVA
rs3388895112	78	Y>F	No	EVA
rs3388884068	105	T>S	No	EVA
rs3388887516	108	A>G	No	EVA
rs3388880932	115	G>D	No	EVA
rs3388892806	125	F>Y	No	EVA
rs3388897260	133	D>E	No	EVA
rs3388865822	144	G>D	No	EVA
rs3388891550	168	P>L	No	EVA
rs3388851341	215	A>G	No	EVA
rs3388884801	235	C>G	No	EVA
rs3388874995	238	L>H	No	EVA
rs3388884069	240	R>P	No	EVA
rs3412895864	270	R>L	No	EVA
rs3388893824	292	S>I	No	EVA
rs3388893860	319	F>L	No	EVA
rs3388865854	343	I>V	No	EVA
rs3388884064	367	H>Q	No	EVA
rs3388884002	391	I>T	No	EVA
rs257620889	400	T>A	No	EVA

Type	Name	Position	InterPro Accession
domain	Phospholipase D/Transphosphatidylase	194 - 221	IPR001736-1
domain	Phospholipase D/Transphosphatidylase	409 - 435	IPR001736-2
domain	PLD-like domain	221 - 400	IPR032803

		Description
EC Number	3.1.16.1	Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type II membrane protein Lysosome lumen Early endosome membrane ; Single-pass type II membrane protein Late endosome membrane ; Single-pass type II membrane protein Golgi apparatus membrane ; Single-pass type II membrane protein Endosome membrane ; Single-pass type II membrane protein	Localizes to ER-associated vesicles in differentiating myotubes The soluble form in lysosome arises by proteolytic processing of the membrane-bound form
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
early endosome membrane	The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane	The lipid bilayer surrounding a late endosome.
lysosomal lumen	The volume enclosed within the lysosomal membrane.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

Name	Definition
phospholipase D activity	Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.
single-stranded DNA 5'-3' exodeoxyribonuclease activity	Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.

Name	Definition
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
myotube differentiation	The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
regulation of cytokine production involved in inflammatory response	Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins