O34858

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU29440
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

244-316 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O34858

Entry ID Method Resolution Chain Position Source
AF-O34858-F1 Predicted AlphaFoldDB

No variants for O34858

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O34858

No associated diseases with O34858

3 regional properties for O34858

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 276 - 285 IPR020557
domain Fumarate lyase, N-terminal 7 - 301 IPR022761
domain Argininosuccinate lyase, C-terminal 364 - 431 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKLWGGRFQ KTPEKWVDEF GASISFDQNL VAEDITGSLA HAAMLKKCGI LTAEEELKIR
70 80 90 100 110 120
EGLNTLLQKA EEGALEFSVD YEDIHLNIEK MLIDEIGPLG GKLHTGRSRN DQVATDMHLY
130 140 150 160 170 180
LKNHVGHIIE LIEAFQSALI EKAEANVETI LPGYTHLQRA QPISFAHHLL AYFWMLERDK
190 200 210 220 230 240
ERFQDSMKRI NKSPLGCGAL AGTTFPIDRD YSAELLGFDA IYENSLDGVS DRDFILEFLS
250 260 270 280 290 300
NSSMLMMHLS RFSEEIILWC SQEFKFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY
310 320 330 340 350 360
GDMMGLFTIM KGLPLAYNKD LQEDKEGMFD TVKTVEGSLQ IFTGMIQTMT VNKDVMKQAT
370 380 390 400 410 420
KQDFSNATEL ADYLAKKGMP FREAHEVVGK LVYTCIERGI YLSDMPFGEF QQASTLFEED
430 440 450 460
IYTVLDPYYA VEKRMSAGGT GFKQVEQALE KAKACVAAGV C