O34757

PR
Gene name
desK (yocF, BSU19190)
Protein name
Sensor histidine kinase DesK
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU19190
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for O34757

Entry ID Method Resolution Chain Position Source
3EHF X-ray 310 A A/B/C/D 175-370 PDB
3EHG X-ray 174 A A 243-370 PDB
3EHH X-ray 210 A A/B 154-370 PDB
3EHJ X-ray 250 A A/B 154-370 PDB
3GIE X-ray 265 A A/B 154-370 PDB
3GIF X-ray 270 A A/B 154-370 PDB
3GIG X-ray 350 A A/B 154-370 PDB
5IUJ X-ray 320 A A/B/D/E 154-370 PDB
5IUK X-ray 290 A A/B/D/E 154-370 PDB
5IUL X-ray 315 A A/B/D/E 154-370 PDB
5IUM X-ray 316 A A/B 154-370 PDB
7SSI X-ray 341 A A/B/D/E 154-370 PDB
7SSJ X-ray 252 A A/C/D 150-370 PDB
AF-O34757-F1 Predicted AlphaFoldDB

No variants for O34757

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O34757

No associated diseases with O34757

1 regional properties for O34757

Type Name Position InterPro Accession
domain Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain 179 - 242 IPR011712

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIKNHFTFQK LNGITPYIWT IFFILPFYFI WKSSSTFVII VGIILTLLFF SVYRFAFVSK
70 80 90 100 110 120
GWTIYLWGFL LIGISTASIT LFSYIYFAFF IAYFIGNIKE RVPFHILYYV HLISAAVAAN
130 140 150 160 170 180
FSLVLKKEFF LTQIPFVVIT LISAILLPFS IKSRKERERL EEKLEDANER IAELVKLEER
190 200 210 220 230 240
QRIARDLHDT LGQKLSLIGL KSDLARKLIY KDPEQAAREL KSVQQTARTS LNEVRKIVSS
250 260 270 280 290 300
MKGIRLKDEL INIKQILEAA DIMFIYEEEK WPENISLLNE NILSMCLKEA VTNVVKHSQA
310 320 330 340 350 360
KTCRVDIQQL WKEVVITVSD DGTFKGEENS FSKGHGLLGM RERLEFANGS LHIDTENGTK
LTMAIPNNSK