O34580

PR
Gene name
pcrA (yerF, BSU06610)
Protein name
ATP-dependent DNA helicase PcrA
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU06610
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

616-715 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O34580

Entry ID Method Resolution Chain Position Source
AF-O34580-F1 Predicted AlphaFoldDB

No variants for O34580

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O34580

No associated diseases with O34580

2 regional properties for O34580

Type Name Position InterPro Accession
domain UvrD-like helicase, ATP-binding domain 10 - 289 IPR014016
domain UvrD-like DNA helicase, C-terminal 280 - 621 IPR014017

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
DNA helicase complex A protein complex that possesses DNA helicase activity.

4 GO annotations of molecular function

Name Definition
3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

2 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNYISNQLLS GLNPVQQEAV KTTDGPLLLM AGAGSGKTRV LTHRIAYLMA EKHVAPWNIL
70 80 90 100 110 120
AITFTNKAAR EMKERVESIL GPGADDIWIS TFHSMCVRIL RRDIDRIGIN RNFSILDTAD
130 140 150 160 170 180
QLSVIKGILK ERNLDPKKFD PRSILGTISS AKNELTEPEE FSKVAGGYYD QVVSDVYADY
190 200 210 220 230 240
QKKLLKNQSL DFDDLIMTTI KLFDRVPEVL EFYQRKFQYI HVDEYQDTNR AQYMLVKQLA
250 260 270 280 290 300
ERFQNLCVVG DSDQSIYRWR GADITNILSF EKDYPNASVI LLEQNYRSTK RILRAANEVI
310 320 330 340 350 360
KNNSNRKPKN LWTENDEGIK ISYYRGDNEF GEGQFVAGKI HQLHSTGKRK LSDIAILYRT
370 380 390 400 410 420
NAQSRVIEET LLKAGLNYNI VGGTKFYDRK EIKDILAYLR LVSNPDDDIS FTRIVNVPKR
430 440 450 460 470 480
GVGATSLEKI ASYAAINGLS FFQAIQQVDF IGVSAKAANA LDSFRQMIEN LTNMQDYLSI
490 500 510 520 530 540
TELTEEILDK TEYREMLKAE KSIEAQSRLE NIDEFLSVTK NFEQKSEDKT LVAFLTDLAL
550 560 570 580 590 600
IADIDQLDQK EEESGGKDAI TLMTLHAAKG LEFPVVFLMG LEEGVFPHSR SLMEEAEMEE
610 620 630 640 650 660
ERRLAYVGIT RAEQELYLTN AKMRTLFGRT NMNPESRFIA EIPDDLLENL NEKKETRATS
670 680 690 700 710 720
ARKMQPRRGP VSRPVSYASK TGGDTLNWAV GDKAGHKKWG TGTVVSVKGE GEGTELDIAF
730
PSPVGVKRLL AAFAPIEKQ