O34002

PR
Gene name
gltA (cisY)
Protein name
2-methylcitrate synthase
Names
2-MCS, MCS, Citrate synthase
Species
Antarctic bacterium DS2-3R
KEGG Pathway
EC number
2.3.3.5: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

76-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O34002

Entry ID Method Resolution Chain Position Source
1A59 X-ray 209 A A 2-379 PDB
AF-O34002-F1 Predicted AlphaFoldDB

No variants for O34002

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O34002

No associated diseases with O34002

1 regional properties for O34002

Type Name Position InterPro Accession
active_site Citrate synthase active site 267 - 279 IPR019810

Functions

Description
EC Number 2.3.3.5 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
2-methylcitrate synthase activity Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
citrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

2 GO annotations of biological process

Name Definition
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEPTIHKGL AGVTADVTAI SKVNSDTNSL LYRGYPVQEL AAKCSFEQVA YLLWNSELPN
70 80 90 100 110 120
DSELKAFVNF ERSHRKLDEN VKGAIDLLST ACHPMDVART AVSVLGANHA RAQDSSPEAN
130 140 150 160 170 180
LEKAMSLLAT FPSVVAYDQR RRRGEELIEP REDLDYSANF LWMTFGEEAA PEVVEAFNVS
190 200 210 220 230 240
MILYAEHSFN ASTFTARVIT STLADLHSAV TGAIGALKGP LHGGANEAVM HTFEEIGIRK
250 260 270 280 290 300
DESLDEAATR SKAWMVDALA QKKKVMGFGH RVYKNGDSRV PTMKSALDAM IKHYDRPEML
310 320 330 340 350 360
GLYNGLEAAM EEAKQIKPNL DYPAGPTYNL MGFDTEMFTP LFIAARITGW TAHIMEQVAD
370
NALIRPLSEY NGPEQRQVP