O33780

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO0602
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O33780

Entry ID Method Resolution Chain Position Source
AF-O33780-F1 Predicted AlphaFoldDB

No variants for O33780

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O33780

No associated diseases with O33780

4 regional properties for O33780

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 242 - 421 IPR002314
domain Aminoacyl-tRNA synthetase, class II 199 - 431 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 7 - 108 IPR015866
domain Serine-tRNA ligase catalytic core domain 121 - 438 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWSILELLR KNPEDLKNNL KRRAIDVSLV DKAVELDKKW RQVLQEVEKL RHQHNVLSSQ
70 80 90 100 110 120
ISKLSGEERK KKIEESKNLL KILEEKEKEL EEIENERDRL LSSLPNLVAD DVPNGPDDSY
130 140 150 160 170 180
NVPIKFWGKF KVYEGDVQEF LKQIKDAKVN YEVIKWKPKG HAEMLEDVLH LGNTLKAAEI
190 200 210 220 230 240
AGSRFYYLFN DIVWLDFSLL LFAIDYITQQ GYTLVLPPYM LRGEVIQSVI DLDTFKDAIY
250 260 270 280 290 300
KIENEDLYLI ATAEHPIAAM FFKEEIEKDK LPLKFAGISP AFRKEASAAN KDLKGIFRVH
310 320 330 340 350 360
QFHKVEQFIF STPEDSWKYH SELITNAESI FQQLELPYRI VNIASGDLGA CAAKKFDLEV
370 380 390 400 410 420
WMPAQAKFRE MVSCSNCTDW QAFRMKIRYV DRKNNRRGYV HTLNSTAIAS TRTITAILEN
430 440 450
YQREDGVVEV PKVLRKYLEA FPKAPKDYIY PLKNKII