O33127

PR
Gene name
ppk
Protein name
Polyphosphate kinase
Names
ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1681
EC number
2.7.4.1: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O33127

Entry ID Method Resolution Chain Position Source
AF-O33127-F1 Predicted AlphaFoldDB

No variants for O33127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O33127

No associated diseases with O33127

4 regional properties for O33127

Type Name Position InterPro Accession
domain Polyphosphate kinase middle domain 164 - 373 IPR024953
domain Polyphosphate kinase N-terminal domain 49 - 155 IPR025198
domain Polyphosphate kinase C-terminal domain 2 556 - 726 IPR025200
domain Polyphosphate kinase, C-terminal domain 1 383 - 549 IPR041108

Functions

Description
EC Number 2.7.4.1 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
polyphosphate kinase complex A protein complex that possesses polyphosphate kinase activity.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
polyphosphate kinase activity Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMSNDLLVTD IEAEARTEEN IWHSDNSALA APPAATTSAS QDQLPDDRYL NRESSWLDFN
70 80 90 100 110 120
ARVLALAADN SLPLLERAKF LAIFASNLDE FYMVRVAGLK RRDEMDLSVR SADGLTPREQ
130 140 150 160 170 180
LSRIGEQTQW IASRHARVFL DSVLPALGEE GIYIVTWTDL DQAERDQLST YFNEQVFPVL
190 200 210 220 230 240
TPLAVDPAHP FPFVSGLSLN LAVTVKQPED GTQHFARVKV PNNVDRFVEL ANRGAVRDTS
250 260 270 280 290 300
AGDEGQLIHR FLPMEELIAA FLPVLFPGTE IVEHHAFRIT RNADFEVEED RDEDLLQALE
310 320 330 340 350 360
RELARRRFGS PVRLEIADDM TESMLELLLR ELDVHPSDVI EVPGLLDLSS LWQIYGLDRP
370 380 390 400 410 420
ALKDRAFIPD THPAFAERET PKSIFATLRE GDVLVHHPYH SFATSVQRFI EQATADPDVL
430 440 450 460 470 480
AIKQTLYRTS GDSPIVLALI EAAEAGKQVV ALVEIKARFD EQANIRWARA LEHAGVHVVY
490 500 510 520 530 540
GIVGLKTHCK TCLVVRREGP TIRRYCHIGT GNYNSKTARL YEDVGLLTAA PDIGADLTDL
550 560 570 580 590 600
FNSLTGYSRK LAYRNLLVAP YGIRRGIIER VEREVAAHRE SGPQTGKGLI RLKMNALVDE
610 620 630 640 650 660
QVIDALYRAS QAGVRVEVVV RGICALRPGT EGFSENIFVR SILGRFLEHS RIIHFRAIDE
670 680 690 700 710 720
FWIGSADMMH RNLDRRVEVL AQVKDSRLTA QLDELLKSAL DPFTRCWELR PDGQWTASPQ
730
KGQQVRDHQE SLMERHRSR