O33117

PR
Gene name
leuB (ML1691, MLCB637.26)
Protein name
3-isopropylmalate dehydrogenase
Names
3-IPM-DH, Beta-IPM dehydrogenase, IMDH
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1691
EC number
1.1.1.85: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-305 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O33117

Entry ID Method Resolution Chain Position Source
AF-O33117-F1 Predicted AlphaFoldDB

No variants for O33117

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O33117

No associated diseases with O33117

2 regional properties for O33117

Type Name Position InterPro Accession
conserved_site Isocitrate/isopropylmalate dehydrogenase, conserved site 247 - 266 IPR019818
domain Isopropylmalate dehydrogenase-like domain 6 - 358 IPR024084

Functions

Description
EC Number 1.1.1.85 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
magnesium ion binding Binding to a magnesium (Mg) ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLAIIGGDG IGPEVVAQAV KILDVVLPGV QKTTYDLGAR RYHTTGELLP ESVLAELREH
70 80 90 100 110 120
DAILLGAVGD PSVPSGVLER GLLLRLRFEL DHHINLRPAR LYPGVNSLLA GKPDIDFVVV
130 140 150 160 170 180
REGTEGPYTG TGGAIRVGTP NEVATEVSVN TAFGVRRVVQ DAFERARQRR KHLTLVHKNN
190 200 210 220 230 240
VLTYAGTLWC RIVQEVGEKY PDVEVVYQHI DAATIYLVTE PSRFDVIVTD NLFGDIITDL
250 260 270 280 290 300
AAAVCGGIAL AASGNIDATR TNPSMFEPVH GSAPDIAGQG IADPTAAIMS LALLLAHLGE
310 320 330
DEPAARLDQA VASYLATRGN GRFSTGEVGE RIAAAL