O33021

PR
Gene name
lepB (ML1612, MLCB250.39)
Protein name
Probable signal peptidase I
Names
SPase I, Leader peptidase I
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1612
EC number
3.4.21.89: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O33021

Entry ID Method Resolution Chain Position Source
AF-O33021-F1 Predicted AlphaFoldDB

No variants for O33021

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O33021

No associated diseases with O33021

3 regional properties for O33021

Type Name Position InterPro Accession
domain Peptidase S26 54 - 272 IPR019533
active_site Peptidase S26A, signal peptidase I, serine active site 82 - 89 IPR019756
conserved_site Peptidase S26A, signal peptidase I, conserved site 221 - 234 IPR019758

Functions

Description
EC Number 3.4.21.89 Serine endopeptidases
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTETTDSVPE PPSDADQLQP KVSICGLDMP AEVSETAAEA AIGVSEPKKR SALWEFAILA
70 80 90 100 110 120
VIAIGLYYVM LTFVARPYLI PSESMEPTLH GCSGCVGDRI MVDKITYRFS SPQPGDVIVF
130 140 150 160 170 180
KGPPSWNTMY KSIRSNNIVL RSVQNALSFV GFVPPDENDL VKRVIAVGGQ TVQCRSDTGL
190 200 210 220 230 240
TVNGKPLKEP YLRPVTMNAD LSFSPCLGSE FGPVTVPQGR LWVMGDNRIH SADSRYHCNS
250 260 270 280
TDVVNGLSCT GDPNSGTVPV SNVIGKARVV VWPPSRWGGV GSVNSQQGQ