O33013
Gene name |
ffh |
Protein name |
Signal recognition particle protein |
Names |
Fifty-four homolog |
Species |
Mycobacterium leprae (strain TN) |
KEGG Pathway |
mle:ML1622 |
EC number |
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O33013
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O33013-F1 | Predicted | AlphaFoldDB |
No variants for O33013
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O33013 | |||||
No associated diseases with O33013
4 regional properties for O33013
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Signal recognition particle, SRP54 subunit, GTPase domain | 100 - 302 | IPR000897 |
| domain | AAA+ ATPase domain | 99 - 307 | IPR003593 |
| domain | Signal recognition particle, SRP54 subunit, M-domain | 334 - 431 | IPR004125 |
| domain | Signal recognition particle SRP54, helical bundle | 1 - 86 | IPR013822 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.4 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| signal recognition particle | A complex of protein and RNA which facilitates translocation of proteins across membranes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7S RNA binding | Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFESLSNRLT | GVIQGLRGKG | RLTDADIEAT | TREIRLALFE | ADVSLPVVRA | FVHRIKERAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTEVSAALNP | AQQIVKIVNE | ELIGILGGET | RQLAFAKTPP | TVVMLAGLQG | SGKTTLAGKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVRLRRQGHT | PLLVACDLQR | PAAVNQLQVV | GERAGVPVFA | PHPGASPDSG | PGDPVAVASA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLVEARAKHF | DVVIVDTAGR | LGIDDELMAQ | AGAIREAINP | DEVLFVLDAM | IGQDAVTTAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AFGAGVGFTG | VVLTKLDGDA | RGGAALSVRE | VTGVPILFAT | TGEKLDDFDV | FHPDRMASRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGMGDVLSLI | EQAEQVFDAE | QAEAAAAKIV | AGELTLEDFL | EQMLAVRKMG | LIGNLLGMLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GAGQVKEVLE | QVDDKQLDRL | QAIIRGMTPQ | ERADPKIINA | SRRLRIANGS | GVTVSEVNQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDRFFEARKM | MSSVLGGMGI | PGMGRKSATR | KSKGGKGKKR | ARGPTSPKVR | SPFGPARPGM |
| 490 | 500 | 510 | 520 | ||
| PDMMNMPPSF | PDLSQMPDGL | NELPPGLAAF | DLSKLKFPGK | T |